PT  - JOURNAL ARTICLE
AU  - Luigi Pisani
AU  - Anna Geke Algera
AU  - Ary Serpa Neto
AU  - Areef Ahsan
AU  - Abigail Beane
AU  - Kaweesak Chittawatanarat
AU  - Abul Faiz
AU  - Rashan Haniffa
AU  - Reza Hashemian
AU  - Madiha Hashmi
AU  - Hisham Ahmed Imad
AU  - Kanishka Indraratna
AU  - Shivakumar Iyer
AU  - Gyan Kayastha
AU  - Bhuvana Krishna
AU  - Hassan Moosa
AU  - Behzad Nadjm
AU  - Rajyabardhan Pattnaik
AU  - Sriram Sampath
AU  - Louise Thwaites
AU  - Ni Ni Tun
AU  - Nor’azim Mohd Yunos
AU  - Salvatore Grasso
AU  - Frederique Paulus
AU  - Marcelo Gama de Abreu
AU  - Paolo Pelosi
AU  - Arjen M Dondorp
AU  - Marcus J Schultz
ED  - ,
TI  - PRactice of VENTilation in Middle-Income Countries (PRoVENT-iMIC): rationale and protocol for a prospective international multicentre observational study in intensive care units in Asia
AID  - 10.1136/bmjopen-2017-020841
DP  - 2018 Apr 01
TA  - BMJ Open
PG  - e020841
VI  - 8
IP  - 4
4099  - http://bmjopen.bmj.com/content/8/4/e020841.short
4100  - http://bmjopen.bmj.com/content/8/4/e020841.full
SO  - BMJ Open2018 Apr 01; 8
AB  - Introduction Current evidence on epidemiology and outcomes of invasively mechanically ventilated intensive care unit (ICU) patients is predominantly gathered in resource-rich settings. Patient casemix and patterns of critical illnesses, and probably also ventilation practices are likely to be different in resource-limited settings. We aim to investigate the epidemiological characteristics, ventilation practices and clinical outcomes of patients receiving mechanical ventilation in ICUs in Asia.Methods and analysis PRoVENT-iMIC (study of PRactice of VENTilation in Middle-Income Countries) is an international multicentre observational study to be undertaken in approximately 60 ICUs in 11 Asian countries. Consecutive patients aged 18 years or older who are receiving invasive ventilation in participating ICUs during a predefined 28-day period are to be enrolled, with a daily follow-up of 7 days. The primary outcome is ventilatory management (including tidal volume expressed as mL/kg predicted body weight and positive end-expiratory pressure expressed as cm H2O) during the first 3 days of mechanical ventilation—compared between patients at no risk for acute respiratory distress syndrome (ARDS), patients at risk for ARDS and in patients with ARDS (in case the diagnosis of ARDS can be made on admission). Secondary outcomes include occurrence of pulmonary complications and all-cause ICU mortality.Ethics and dissemination PRoVENT-iMIC will be the first international study that prospectively assesses ventilation practices, outcomes and epidemiology of invasively ventilated patients in ICUs in Asia. The results of this large study, to be disseminated through conference presentations and publications in international peer-reviewed journals, are of ultimate importance when designing trials of invasive ventilation in resource-limited ICUs. Access to source data will be made available through national or international anonymised datasets on request and after agreement of the PRoVENT-iMIC steering committee.Trial registration number NCT03188770; Pre-results.