RT Journal Article
SR Electronic
T1 Wait a minute? An observational cohort study comparing iron stores in healthy Swedish infants at 4 months of age after 10-, 60- and 180-second umbilical cord clamping
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e017215
DO 10.1136/bmjopen-2017-017215
VO 7
IS 12
A1 Ulrica Askelöf
A1 Ola Andersson
A1 Magnus Domellöf
A1 Anders Fasth
A1 Boubou Hallberg
A1 Lena Hellström-Westas
A1 Karin Pettersson
A1 Magnus Westgren
A1 Ingela E Wiklund
A1 Cecilia Götherström
YR 2017
UL http://bmjopen.bmj.com/content/7/12/e017215.abstract
AB Background and objective Umbilical cord blood (UCB) is a valuable stem cell source used for transplantation. Immediate umbilical cord (UC) clamping is widely practised, but delayed UC clamping is increasingly advocated to reduce possible infant anaemia. The aim of this study was to investigate an intermediate UC clamping time point and to evaluate iron status at the age of 4 months in infants who had the UC clamped after 60 s and compare the results with immediate and late UC clamping.Design Prospective observational study with two historical controls.Setting A university hospital in Stockholm, Sweden, and a county hospital in Halland, Sweden.Methods Iron status was assessed at 4 months in 200 prospectively recruited term infants whose UC was clamped 60 s after birth. The newborn baby was held below the uterine level for the first 30 s before placing the infant on the mother’s abdomen for additional 30 s. The results were compared with data from a previously conducted randomised controlled trial including infants subjected to UC clamping at ≤10 s (n=200) or ≥180 s (n=200) after delivery.Results After adjustment for age differences at the time of follow-up, serum ferritin concentrations were 77, 103 and 114 µg/L in the 10, 60 and 180 s groups, respectively. The adjusted ferritin concentration was significantly higher in the 60 s group compared with the 10 s group (P=0.002), while the difference between the 60 and 180 s groups was not significant (P=0.29).Conclusion In this study of healthy term infants, 60 s UC clamping with 30 s lowering of the baby below the uterine level resulted in higher serum ferritin concentrations at 4 months compared with 10 s UC clamping. The results suggest that delaying the UC clamping for 60 s reduces the risk for iron deficiency.Trial registration number NCT01245296.