RT Journal Article
SR Electronic
T1 Prevalence and risk factors of eye diseases in adult patients with obstructive sleep apnoea: results from the SLE.E.P.Y cohort study
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e016142
DO 10.1136/bmjopen-2017-016142
VO 7
IS 10
A1 Emilio Pedrotti
A1 Christian Luigi Demasi
A1 Enrico Bruni
A1 Francesca Bosello
A1 Paolo Plinio Di Sarro
A1 Mattia Passilongo
A1 Adriano Fasolo
A1 Nicola Gennaro
A1 Alessandra De Gregorio
A1 Marcello Ferrari
A1 Giorgio Marchini
YR 2017
UL http://bmjopen.bmj.com/content/7/10/e016142.abstract
AB Objectives To assess the occurrence of glaucoma, eyelid, corneal and macular disorders in a cohort of patients with obstructive sleep apnoea (OSA) diagnosed by overnight polysomnography and to investigate into the risk factors for the above eye diseases (EDs).Design Cross-sectional cohort study between 2014 and 2015.Setting Unit of Respiratory Medicine and Eye Clinic of the University of Verona.Participants 431 consecutive patients were considered eligible. Of these, 87 declined to participate, 35 were untraceable and 13 were deceased.Interventions A complete ophthalmic evaluation of both eyes for each patient.Primary and secondary outcome measures Best-corrected distance visual acuity, intraocular pressure, corneal, macular and optic nerve optical coherence tomography, ocular aberrometry, optic nerve laser polarimetry, visual field test, and eyelid examination.Results 296 patients aged 64.5±12.8 years, 23% female and 77% male, underwent ophthalmic examination. There was 56% (n=166) prevalence of eyelid disorders, 27% (n=80) of corneal disorders, 13% (n=39) of macular disorders and 11% (n=33) of glaucoma. Advancing age was not associated with the severity of OSA, while significant differences were found for gender, body mass index, Oxygen Desaturation Index, smoking habit, hypertension and diabetes. Severe OSA was significantly associated with glaucoma (OR, 95% CI 1.05 to 5.93, p=0.037).Conclusions EDs were more prevalent in our patinets with OSA than in the general population. Severe Apnoea/Hypopnoea Index level seemed to play a role as risk factor only for glaucoma.