RT Journal Article
SR Electronic
T1 Clinical examination, critical care ultrasonography and outcomes in the critically ill: cohort profile of the Simple Intensive Care Studies-I
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e017170
DO 10.1136/bmjopen-2017-017170
VO 7
IS 9
A1 Bart Hiemstra
A1 Ruben J Eck
A1 Geert Koster
A1 Jørn Wetterslev
A1 Anders Perner
A1 Ville Pettilä
A1 Harold Snieder
A1 Yoran M Hummel
A1 Renske Wiersema
A1 Anne Marie G A de Smet
A1 Frederik Keus
A1 Iwan C C van der Horst
A1 ,
YR 2017
UL http://bmjopen.bmj.com/content/7/9/e017170.abstract
AB Purpose In the Simple Intensive Care Studies-I (SICS-I), we aim to unravel the value of clinical and haemodynamic variables obtained by physical examination and critical care ultrasound (CCUS) that currently guide daily practice in critically ill patients. We intend to (1) measure all available clinical and haemodynamic variables, (2) train novices in obtaining values for advanced variables based on CCUS in the intensive care unit (ICU) and (3) create an infrastructure for a registry with the flexibility of temporarily incorporating specific (haemodynamic) research questions and variables. The overall purpose is to investigate the diagnostic and prognostic value of clinical and haemodynamic variables.Participants The SICS-I includes all patients acutely admitted to the ICU of a tertiary teaching hospital in the Netherlands with an ICU stay expected to last beyond 24 hours. Inclusion started on 27 March 2015.Findings to date On 31 December 2016, 791 eligible patients fulfilled our inclusion criteria of whom 704 were included. So far 11 substudies with additional variables have been designed, of which six were feasible to implement in the basic study, and two are planned and awaiting initiation. All researchers received focused training for obtaining specific CCUS images. An independent Core laboratory judged that 632 patients had CCUS images of sufficient quality.Future plans We intend to optimise the set of variables for assessment of the haemodynamic status of the critically ill patient used for guiding diagnostics, prognosis and interventions. Repeated evaluations of these sets of variables are needed for continuous improvement of the diagnostic and prognostic models. Future plans include: (1) more advanced imaging; (2) repeated clinical and haemodynamic measurements; (3) expansion of the registry to other departments or centres; and (4) exploring possibilities of integration of a randomised clinical trial superimposed on the registry.Study registration number NCT02912624; Pre-results.