TY - JOUR T1 - Relationship between estimated cardiovascular disease risk and insulin resistance in a black African population living with HIV: a cross-sectional study from Cameroon JF - BMJ Open JO - BMJ Open DO - 10.1136/bmjopen-2017-016835 VL - 7 IS - 8 SP - e016835 AU - Steve Raoul Noumegni AU - Jean Joel Bigna AU - Vicky Jocelyne Ama Moor epse Nkegoum AU - Jobert Richie Nansseu AU - Felix K Assah AU - Ahmadou Musa Jingi AU - Magellan Guewo-Fokeng AU - Steve Leumi AU - Jean-Claude Katte AU - Mesmin Y Dehayem AU - Liliane Mfeukeu Kuate AU - Andre Pascal Kengne AU - Eugene Sobngwi Y1 - 2017/08/01 UR - http://bmjopen.bmj.com/content/7/8/e016835.abstract N2 - Objectives Cardiovascular disease (CVD) and metabolic diseases are growing concerns among patients with HIV infection as a consequence of the improving survival of this population. We aimed to assess the relationship between CVD risk and insulin resistance in a group of black African individuals with HIV infection.Methods This cross-sectional study involved patients with HIV infection aged 30–74 years and followed up at the Yaoundé Central Hospital, Cameroon. Absolute CVD risk was calculated using the Framingham and the DAD CVD risk equations while the HOMA-IR index was used to assess insulin resistance (index ≥2.1).Results A total of 452 patients (361 women; 80%) were screened. The mean age was 44.4 years and most of the respondents were on antiretroviral therapy (88.5%). The median 5-year cardiovascular risk was 0.7% (25th−75th percentiles: 0.2–2.0) and 0.6% (0.3–1.3) according to the Framingham and DAD equations respectively. Of all participants, 47.3% were insulin resistant. The Framingham equation derived absolute CVD risk was significantly associated with insulin resistance; while no linear association was found using the DAD equation.Conclusion The relationship between cardiovascular risk and insulin resistance in black African patients with HIV infection seems to depend on the cardiovascular risk equation used. ER -