TY - JOUR T1 - Are thyroid nodules associated with sex-related hormones? A cross-sectional SPECT-China study JF - BMJ Open JO - BMJ Open DO - 10.1136/bmjopen-2016-015812 VL - 7 IS - 8 SP - e015812 AU - Yi Chen AU - Yingchao Chen AU - Ningjian Wang AU - Chi Chen AU - Xiaomin Nie AU - Qin Li AU - Bing Han AU - Fangzhen Xia AU - Hualing Zhai AU - Boren Jiang AU - Zhoujun Shen AU - Yingli Lu Y1 - 2017/08/01 UR - http://bmjopen.bmj.com/content/7/8/e015812.abstract N2 - Objective Little is known about the association between thyroid nodules (TNs) and endogenous sex hormones. We aimed to investigate the relationship between TNs and sex-related hormones among men in China.Setting The data were obtained from a cross-sectional study Survey on Prevalence in East China for Metabolic Diseases and Risk Factors (SPECT-China study, 2014–2015) based on the population.Participants In total, 4024 men over 18 years of age who were not using hormone replacement therapy and who underwent complete assays of the serum total testosterone (T), oestradiol (E2), follicle-stimulating hormone (FSH), luteinising hormone (LH) and sex hormone-binding globulin (SHBG) levels as well as thyroid ultrasonography (US) enrolled in this study.Results Of the 4024 participants (54.15±13.08 years old), 1667 participants (41.4%) had TNs. Men with TN(s) (TN(+) group) had significantly lower levels of total T and SHBG and higher E2/T levels compared with the men without TN(s) (TN(−) group) (p<0.05). The TN prevalence decreased with the quartiles of the SHBG level (p<0.05). Binary logistic analysis showed that lower quartiles of SHBG had a greater risk of TN(s) (all p for trend <0.05). This association persisted in the fully adjusted model (p for trend=0.017), in which, for the lowest compared with the highest quartile of SHBG, the OR of TN(s) was 1.42 (95% CI 1.07 to 1.89). No statistically significant association was found between sex-related hormones and US characteristics associated with malignancy (nodule >10 mm, microcalcification and a ‘taller’ than ‘wider’ shape).Conclusions TNs are highly prevalent in men in China. A lower SHBG level was significantly associated with TN among men. The potential role of SHBG in the pathogenesis of the TN remains to be elucidated. ER -