RT Journal Article
SR Electronic
T1 Serum fibrinogen and cardiovascular events in Chinese patients with type 2 diabetes and stable coronary artery disease: a prospective observational study
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e015041
DO 10.1136/bmjopen-2016-015041
VO 7
IS 6
A1 Yang, Sheng-Hua
A1 Du, Ying
A1 Zhang, Yan
A1 Li, Xiao-Lin
A1 Li, Sha
A1 Xu, Rui-Xia
A1 Zhu, Cheng-Gang
A1 Guo, Yuan-Lin
A1 Wu, Na-Qiong
A1 Qing, Ping
A1 Gao, Ying
A1 Cui, Chuan-Jue
A1 Dong, Qian
A1 Sun, Jing
A1 Li, Jian-Jun
YR 2017
UL http://bmjopen.bmj.com/content/7/6/e015041.abstract
AB Objectives The aim of this study was to investigate the association of serum fibrinogen with cardiovascular events (CVE) in Chinese patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease (CAD).Design An observational study.Setting FuWai Hospital in Beijing, China.Participants A cohort of 1466 patients with T2DM and angiographic-proven stable CAD was evaluated.Outcome measures Baseline serum fibrinogen levels were measured and trisected into ‘low’, ‘middle’ and ‘high’. Their association with CVE was explored using Cox proportional hazard models.Results With 20.2 months (average) follow-up, 44 (3%) were lost to follow-up and 96 patients developed CVE. Compared with the patients without CVE, the ones who developed CVE had higher levels of fibrinogen. Univariable regression revealed a significant relation of fibrinogen to CVE (HR (HR) 1.25, 95% CI 1.06 to 1.47, p=0.010) per SD increase of fibrinogen at baseline. After adjusting for multiple established cardiovascular disease (CVD) risk factors, the association persisted (HR 1.30, 95% CI 1.02 to 1.66, p=0.037). Moreover, after adjusting for CVD risk factors, the HRs for middle-serum and high-serum fibrinogen concentration, using ‘low’ group as reference, were 1.23 (95% CI 0.69 to 2.20) and 2.20 (95% CI 1.11 to 3.36, p=0.049).Conclusions We first indicated that elevated fibrinogen level was independently associated with increased CVE in Chinese patients with T2DMand stable CAD.