TY - JOUR T1 - Serum fibrinogen and cardiovascular events in Chinese patients with type 2 diabetes and stable coronary artery disease: a prospective observational study JF - BMJ Open JO - BMJ Open DO - 10.1136/bmjopen-2016-015041 VL - 7 IS - 6 SP - e015041 AU - Sheng-Hua Yang AU - Ying Du AU - Yan Zhang AU - Xiao-Lin Li AU - Sha Li AU - Rui-Xia Xu AU - Cheng-Gang Zhu AU - Yuan-Lin Guo AU - Na-Qiong Wu AU - Ping Qing AU - Ying Gao AU - Chuan-Jue Cui AU - Qian Dong AU - Jing Sun AU - Jian-Jun Li Y1 - 2017/06/01 UR - http://bmjopen.bmj.com/content/7/6/e015041.abstract N2 - Objectives The aim of this study was to investigate the association of serum fibrinogen with cardiovascular events (CVE) in Chinese patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease (CAD).Design An observational study.Setting FuWai Hospital in Beijing, China.Participants A cohort of 1466 patients with T2DM and angiographic-proven stable CAD was evaluated.Outcome measures Baseline serum fibrinogen levels were measured and trisected into ‘low’, ‘middle’ and ‘high’. Their association with CVE was explored using Cox proportional hazard models.Results With 20.2 months (average) follow-up, 44 (3%) were lost to follow-up and 96 patients developed CVE. Compared with the patients without CVE, the ones who developed CVE had higher levels of fibrinogen. Univariable regression revealed a significant relation of fibrinogen to CVE (HR (HR) 1.25, 95% CI 1.06 to 1.47, p=0.010) per SD increase of fibrinogen at baseline. After adjusting for multiple established cardiovascular disease (CVD) risk factors, the association persisted (HR 1.30, 95% CI 1.02 to 1.66, p=0.037). Moreover, after adjusting for CVD risk factors, the HRs for middle-serum and high-serum fibrinogen concentration, using ‘low’ group as reference, were 1.23 (95% CI 0.69 to 2.20) and 2.20 (95% CI 1.11 to 3.36, p=0.049).Conclusions We first indicated that elevated fibrinogen level was independently associated with increased CVE in Chinese patients with T2DMand stable CAD. ER -