PT  - JOURNAL ARTICLE
AU  - Yang, Sheng-Hua
AU  - Du, Ying
AU  - Zhang, Yan
AU  - Li, Xiao-Lin
AU  - Li, Sha
AU  - Xu, Rui-Xia
AU  - Zhu, Cheng-Gang
AU  - Guo, Yuan-Lin
AU  - Wu, Na-Qiong
AU  - Qing, Ping
AU  - Gao, Ying
AU  - Cui, Chuan-Jue
AU  - Dong, Qian
AU  - Sun, Jing
AU  - Li, Jian-Jun
TI  - Serum fibrinogen and cardiovascular events in Chinese patients with type 2 diabetes and stable coronary artery disease: a prospective observational study
AID  - 10.1136/bmjopen-2016-015041
DP  - 2017 Jun 01
TA  - BMJ Open
PG  - e015041
VI  - 7
IP  - 6
4099  - http://bmjopen.bmj.com/content/7/6/e015041.short
4100  - http://bmjopen.bmj.com/content/7/6/e015041.full
SO  - BMJ Open2017 Jun 01; 7
AB  - Objectives The aim of this study was to investigate the association of serum fibrinogen with cardiovascular events (CVE) in Chinese patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease (CAD).Design An observational study.Setting FuWai Hospital in Beijing, China.Participants A cohort of 1466 patients with T2DM and angiographic-proven stable CAD was evaluated.Outcome measures Baseline serum fibrinogen levels were measured and trisected into ‘low’, ‘middle’ and ‘high’. Their association with CVE was explored using Cox proportional hazard models.Results With 20.2 months (average) follow-up, 44 (3%) were lost to follow-up and 96 patients developed CVE. Compared with the patients without CVE, the ones who developed CVE had higher levels of fibrinogen. Univariable regression revealed a significant relation of fibrinogen to CVE (HR (HR) 1.25, 95% CI 1.06 to 1.47, p=0.010) per SD increase of fibrinogen at baseline. After adjusting for multiple established cardiovascular disease (CVD) risk factors, the association persisted (HR 1.30, 95% CI 1.02 to 1.66, p=0.037). Moreover, after adjusting for CVD risk factors, the HRs for middle-serum and high-serum fibrinogen concentration, using ‘low’ group as reference, were 1.23 (95% CI 0.69 to 2.20) and 2.20 (95% CI 1.11 to 3.36, p=0.049).Conclusions We first indicated that elevated fibrinogen level was independently associated with increased CVE in Chinese patients with T2DMand stable CAD.