RT Journal Article SR Electronic T1 Long-term responses to treatment in UK veterans with military-related PTSD: an observational study JF BMJ Open JO BMJ Open FD British Medical Journal Publishing Group SP e011667 DO 10.1136/bmjopen-2016-011667 VO 6 IS 9 A1 Murphy, Dominic A1 Spencer-Harper, Lucy A1 Carson, Carron A1 Palmer, Emily A1 Hill, Kate A1 Sorfleet, Nicola A1 Wessely, Simon A1 Busuttil, Walter YR 2016 UL http://bmjopen.bmj.com/content/6/9/e011667.abstract AB Objectives Military-related trauma can be difficult to treat. Evaluating longer term responses to treatment and identifying which individuals may need additional support could inform clinical practice. We assessed 1-year outcomes in UK veterans treated for post-traumatic stress disorder (PTSD).Design Within-participant design.Setting The intervention was offered by Combat Stress, a mental health charity for veterans in the UK.Participants The sample included 401 veterans who completed a standardised 6-week residential treatment. Of these, 268 (67%) were successfully followed up a year after the end of treatment.Methods A range of health outcomes were collected pretreatment and repeated at standard intervals post-treatment. The primary outcome was severity of PTSD symptoms, and secondary outcomes included measures of other mental health difficulties (depression, anxiety and anger), problems with alcohol, and social and occupational functioning.Results Significant reductions in PTSD severity were observed a year after treatment (PSS-I: −11.9, 95% CI −13.1 to −10.7). Reductions in the secondary outcomes were also reported. Higher levels of post-treatment functional impairment (0.24, 95% CI 0.08 to 0.41) and alcohol problems (0.18, 95% CI 0.03 to 0.32) were associated with poorer PTSD treatment response at 12 months.Conclusions This uncontrolled study suggests the longer term benefits of a structured programme to treat UK veterans with PTSD. Our findings point to the importance of continued support targeted for particular individuals post-treatment to improve longer term outcomes.