TY - JOUR T1 - Weight for gestational age and metabolically healthy obesity in adults from the Haguenau cohort JF - BMJ Open JO - BMJ Open DO - 10.1136/bmjopen-2016-011367 VL - 6 IS - 8 SP - e011367 AU - Joane Matta AU - Claire Carette AU - Claire Levy Marchal AU - Julien Bertrand AU - Mélanie Pétéra AU - Marie Zins AU - Estelle Pujos-Guillot AU - Blandine Comte AU - Sébastien Czernichow Y1 - 2016/08/01 UR - http://bmjopen.bmj.com/content/6/8/e011367.abstract N2 - Background An obesity subphenotype, named ‘metabolically healthy obese’ (MHO) has been recently defined to characterise a subgroup of obese individuals with less risk for cardiometabolic abnormalities. To date no data are available on participants born with small weight for gestational age (SGA) and the risk of metabolically unhealthy obesity (MUHO).Objective Assess the risk of MUHO in SGA versus appropriate for gestational age (AGA) adult participants.Methods 129 young obese individuals (body mass index ≥30 kg/m²) from data of an 8-year follow-up Haguenau cohort (France), were identified out of 1308 participants and were divided into 2 groups: SGA (n=72) and AGA (n=57). Metabolic characteristics were analysed and compared using unpaired t-test. The HOMA-IR index was determined for the population and divided into quartiles. Obese participants within the first 3 quartiles were considered as MHO and those in the fourth quartile as MUHO. Relative risks (RRs) and 95% CI for being MUHO in SGA versus AGA participants were computed.Results The SGA-obese group had a higher risk of MUHO versus the AGA-obese group: RR=1.27 (95% CI 1.10 to 1.6) independently of age and sex.Conclusions In case of obesity, SGA might confer a higher risk of MUHO compared with AGA. ER -