320 e-Letters

published between 2011 and 2014

  • Treatment delay affects clinical severity of tuberculosis: a longitudinal cohort study
    Pruthu T K

    Dear Sir, We read the article titled "Treatment delay affects clinical severity of tuberculosis: a longitudinal cohort study" published in BMJ open. The article was interesting as tuberculosis (TB) treatment delay is one of the important issues in timely case detection and management of TB in developing countries. The article was well written. However we have few comments to share which will further facilitate the under...

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  • Fruit and vegetables in the diet and mental well-being
    Celia M. Ross

    The findings of Stranges, et al (2014) that fruit and vegetable consumption was associated with mental well-being brought to mind some other findings (1). There could be numerous mechanisms to explain these results; however, a few jump readily to mind.

    It has been asserted that oxidative stress may play a role in anxiety (2). A diet containing ample amounts of fruits and vegetables, which are rich in antioxidant...

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  • Reply to Ole Olsen
    Oejvind Lidegaard

    Thanks to Ole Olsen for calling attention to a possible inconsistency between the data included in our paper and official stillbirth statistics.

    We always make our own data retrieval from the raw data in the National registries, including the birth registry rather than relying on the official statistics.

    First the official statistics often and also in this case are inconsistent. According to the offic...

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  • Trial protocol must explain how possible adverse effects will be looked for and managed
    Andrew Herxheimer

    Grigg and colleagues have published their design for the first-ever randomised controlled in Plasmodium knowlesi malaria, to be carried out over a 2-year period in Sabah [1]. We are concerned because one arm of the trial involves a fixed combination of mefloquine + artesunate.

    The authors of the study protocol rightly acknowledge that mefloquine is associated with neuropsychiatric adverse events (AEs), but go on...

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  • Correction: Ambulatory blood pressure adds little to Framingham Risk Score for the primary prevention of cardiovascular disease in older men: secondary analysis of observational study data
    Katy J. L. Bell

    The correct affiliation for Andrew Hayen is: School of Public Health and Community Medicine, The University of New South Wales, Sydney, New South Wales, Australia

    Conflict of Interest:

    None declared

  • Correction for the reference 28
    Yao Jie Xie

    The 28th reference cited in this article should be corrected as:

    28. Xie Y, Ho SC. Prenotification had no additional effect on the response rate and survey quality: a randomized trial. J Clin Epidemiol 2013;66:1422-6.

    Conflict of Interest:

    None declared

  • Stillbirth data seem incorrect
    Ole Olsen

    "The registry is considered complete through the period" Hedegaard et al state in their registry study (1) without a supporting reference. However, there seem to be an issue with the quality of the data as the number of stillbirths deviate from the published official statistics. The authors in their online supplement report 539 stillbirths in 2009-10 decreasing to 489 in 2011-12. But according to the published official s...

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  • Response: Assessing the effect of an interactive decision-aid smartphone smoking cessation application (app) on quit rates: a double-blind automated randomised control trial protocol
    Sandeep Tak

    Author have come out with an interesting concept of using smart phone app in medical research. Smart phones are rapidly becoming omnipresent with greater processing power and memory and now are commonly used as first device to access information from or off internet. Thousands of medical apps are available for layman to get information regarding diseases. Also, several apps are available to physicians to quickly asses in...

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  • Does CAM training for GPs really reduce healthcare costs?
    Christopher J. Sampson

    I read with interest the recent contribution from Baars and Kooreman [1]. The present study is a replication of a previous study, using a different data set, as described by the authors in their introduction. The 2012 study by Kooreman and Baars [2] garnered criticism from me and others [3-5]. Furthermore, the new study was also presented in an earlier form [6], and this also faced criticism [7,8]. Baars and Kooreman provid...

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  • Re: Herbal medicine (Gan Mai Da Zao decoction) for depression: a systematic review protocol
    Nozomu Kawashima

    This is a very interesting research proposal to evaluate a formula originated from Chinese traditional medicine, Gan Mai Da Zao (GMDZ) decoction. The protocol for a systematic review is generally well written; however, there are several points that need to be addressed from the standpoint of Japanese traditional Kampo medicine, which incorporated the Gan Mai Da Zao decoction as kambakutaisoto.

    Kampo medicine ori...

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