Measurement properties of patient-reported outcome measures (PROMs) used in adult patients with chronic kidney disease: a systematic review protocol

Introduction Chronic kidney disease (CKD) is associated with symptoms that can significantly reduce the quality of life (QoL) of patients. Patient-reported outcome measures (PROMs) may facilitate the assessment of the impact of disease and treatment on the QoL, from a patient perspective. PROMs can be used in research and routine clinical practice. Methods and analysis A systematic review of studies evaluating the measurement properties of PROMs in adults with CKD will be conducted. MEDLINE, EMBASE, PsycINFO and CINAHL Plus will be systematically searched from inception. Hand searching of reference lists and citations of included studies will be carried out. 2 reviewers will independently screen the titles and abstracts of all the studies retrieved during the systematic search to determine their eligibility. The COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) checklist will be used to appraise the methodological quality of the selected studies following the full-text review. Data on the study population, questionnaire characteristics and measurement properties will be extracted from the selected papers. Finally, a narrative synthesis of extracted data will be undertaken. Ethics and dissemination Ethical permissions are not required for this study as data from published research articles will be used. Findings will be disseminated through publication in a peer-reviewed journal and presented at conferences. This systematic review will provide a comprehensive assessment of the measurement properties of PROMs currently available for use in adult patients with CKD and present evidence which may inform the selection of measures for use in research and clinical practice. Trial registration number CRD42016035554.


EMBASE (Ovid) 1974 to 21/12/15
Note: Set 4 is the sensitive search filter for measurement properties developed by Terwee et al. and adapted for EMBASE. [2] 1. (Renal replacement therapy or APD or Automated Peritoneal Dialysis or CAPD, Continuous Ambulatory Peritoneal Dialysis or CCPD or Continuous cyclic peritoneal dialysis or dialysis or h*emofiltration or h*emodiafiltration or h*emodialysis or kidney transplant* or predialysis or renal replacement or renal transplant*).mp.
2. (CRF or chronic renal failure or CKF or chronic kidney failure or kidney disease* or renal disease or kidney failure or renal failure or CKD or chronic kidney disease or ESKD or end stage kidney disease or ESKF or end stage kidney failure or ESRF or end stage renal failure or ESRD or end stage renal disease or kidney insufficiency).mp.
3. (PRO integration or Clinical PRO application* or telePRO or automated PRO algorithm* or screening purpose* or PRO questionnaire* or Patient-reported outcome questionnaire* or Patient-reported symptom* or Patient-centred care or Patient self-report* or Self-report health or Self-rated health or Self-reported measure* of health or Health outcome* or Health communication* or Hospital performance evaluation* or Automated telephone survey system* or paper-based survey* or web-based survey* or web-based PRO platform* or web-based system* or PRO collection* or PRO measure* or PRO intervention* or PRO assessment intervention* or PRO data or PRO assessment* or Routine PRO assessment* or Routine PRO collection or Symptom assessment* or Symptom monitoring or Symptom data or Functional status or Electronic PRO assessment* or Electronic PRO system* or ePRO or ePRO* or ePRO system* or PRO system* or Generic PRO system* or PRO-based clinical alert system*).mp. 4. ((exp questionnaire/ or exp named inventories/ or questionnaires/) and rating scales/) or exp psychometry/ or exp outcome assessment/ or exp pain assessment/ or exp disability/ or exp validity/ or exp reliability/ 5. *patient/ or *outcome assessment/ or *questionnaire/ or *"quality of life"/ or *self report/ 6. 3 or 4 7. 1 or 2 8. 5 and 6 and 7 PsycINFO (Ovid) 1967 to 21/12/15 Note: Sets 1 to 6 are based on the Oxford PROM Filter.[1] Set 11 is the sensitive search filter for measurement properties developed by Terwee et al. [2] 1. (HR-PRO or HRPRO or HRQL or HRQoL or QL or QoL).ti,ab.
4. health status.mp. 5. ((patient or self or child or parent or carer or proxy) adj (appraisal* or appraised or report or reported or reporting or rated or rating or based or assessed or assessment*)).ti,ab.
6. ((disability or function or functional or functions or subjective or utility or utilities or wellbeing or well being) adj2 (index or indices or instrument or instruments or measure or measures or questionnaire* or profile or profiles or scale or scales or score or scores or status or survey or surveys)).ti,ab. 8. 1 or 2 or 3 or 4 or 5 or 6 or 7 9. (Renal replacement therapy or APD or Automated Peritoneal Dialysis or CAPD, Continuous Ambulatory Peritoneal Dialysis or CCPD or Continuous cyclic peritoneal dialysis or dialysis or h*emofiltration or h*emodiafiltration or h*emodialysis or kidney transplant* or predialysis or renal replacement or renal transplant*).mp. 10. (CRF or chronic renal failure or CKF or chronic kidney failure or kidney disease* or renal disease or kidney failure or renal failure or CKD or chronic kidney disease or ESKD or end stage kidney disease or ESKF or end stage kidney failure or ESRF or end stage renal failure or ESRD or end stage renal disease or kidney insufficiency).mp.