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Population health bio-phenotypes in 11–12 year old children and their midlife parents: Growing Up in Australia’s Child Health CheckPoint
  1. Melissa Wake1,2,3,
  2. Susan A Clifford1,2
  1. 1 Murdoch Children’s Research Institute, Parkville, Victoria, Australia
  2. 2 Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia
  3. 3 Department of Paediatrics and The Liggins Institute, The University of Auckland, Auckland, New Zealand
  1. Correspondence to Professor Melissa Wake; melissa.wake{at}mcri.edu.au

Abstract

In an ambitious undertaking, Growing Up in Australia’s Child Health CheckPoint streamlined and implemented wide-ranging population phenotypes and biosamples relevant to non-communicable diseases in nearly 1900 parent–child dyads throughout Australia at child aged 11–12 years. This BMJ Open Special Issue describes the methodology, epidemiology and parent–child concordance of 14 of these phenotypes, spanning cardiovascular, respiratory, bone, kidney, hearing and language, body composition, metabolic profiles, telomere length, sleep, physical activity, snack choice and health-related quality of life. The Special Issue also includes a cohort summary and study methodology paper.

  • phenotypes
  • reference values
  • children
  • parents
  • inheritance patterns
  • cross-sectional studies

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Footnotes

  • Contributors Both authors conceived, cowrote, read and approved the manuscript.

  • Funding This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (Project Grants 1041352, 1109355), The Royal Children’s Hospital Foundation (2014-241), the Murdoch Children’s Research Institute (MCRI), The University of Melbourne, the National Heart Foundation of Australia (100660) and the Financial Markets Foundation for Children (2014-055, 2016-310). MW was supported by the NHMRC (Senior Research Fellowship 1046518, Principal Research Fellowship 1160906) and Cure Kids New Zealand. The MCRI administered the research grants for the study and provided infrastructural support (IT and biospecimen management) to its staff and the study but played no role in the conduct or analysis of the trial. The Australian Department of Social Services played a role in study design; however, no other funding bodies had a role in the study design and conduct; data collection, management, analysis and interpretation; preparation, review or approval of the manuscript and decision to submit the manuscript for publication. Research at the MCRI is supported by the Victorian Government’s Operational Infrastructure Support Program.

  • Competing interests All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare financial support as described in the funding section.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Data sharing statement The Longitudinal Study of Australian Children datasets and technical documents are available to researchers at no cost via a licence agreement. Data access requests are co-ordinated by the National Centre for Longitudinal Data. More information is available at https://dataverse.ada.edu.au/dataverse/lsac.

  • Patient consent for publication Not required.

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