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  • Simple risk score based on the China Acute Myocardial Infarction registry for predicting in-hospital mortality among patients with non-ST-segment elevation myocardial infarction: results of a prospective observational cohort study

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Cardiovascular medicine
Original research
Simple risk score based on the China Acute Myocardial Infarction registry for predicting in-hospital mortality among patients with non-ST-segment elevation myocardial infarction: results of a prospective observational cohort study
  1. Chenxi Song1,
  2. Rui Fu1,
  3. Sidong Li2,
  4. Jingang Yang1,
  5. Yan Wang3,
  6. Haiyan Xu1,
  7. Xiaojin Gao1,
  8. Jia Liu2,
  9. Qianqian Liu1,
  10. Chunyue Wang1,
  11. Kefei Dou1,
  12. Yuejin Yang1
  1. 1 Coronary Heart Disease Center, Fuwai Hospital, Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases, Peking Union Medical College, Beijing, China
  2. 2 Medical Research and Biometrics Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  3. 3 Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen University, Beijing, China
  1. Correspondence to Dr Yuejin Yang; yangyjfw{at}126.com

Abstract

Objectives To simplify our previous risk score for predicting the in-hospital mortality risk in patients with non-ST-segment elevation myocardial infarction (NSTEMI) by dropping laboratory data.

Design Prospective cohort.

Setting Multicentre, 108 hospitals across three levels in China.

Participants A total of 5775 patients with NSTEMI enrolled in the China Acute Myocardial Infarction (CAMI) registry.

Primary outcome measures In-hospital mortality.

Results The simplified CAMI-NSTEMI (SCAMI-NSTEMI) score includes the following nine variables: age, body mass index, systolic blood pressure, Killip classification, cardiac arrest, ST-segment depression on ECG, smoking status, previous angina and previous percutaneous coronary intervention. Within both the derivation and validation cohorts, the SCAMI-NSTEMI score showed a good discrimination ability (C-statistics: 0.76 and 0.83, respectively); further, the SCAMI-NSTEMI score had a diagnostic performance superior to that of the Global Registry of Acute Coronary Events risk score (C-statistics: 0.78 and 0.73, respectively; p<0.0001 for comparison). The in-hospital mortality increased significantly across the different risk groups.

Conclusions The SCAMI-NSTEMI score can serve as a useful tool facilitating rapid risk assessment among a broader spectrum of patients admitted owing to NSTEMI.

Trial registration number NCT01874691.

  • NSTEMI
  • updated risk score
  • in-hospital mortality

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2019-030772

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    Footnotes

    • Contributors RF and CS were major contributors in writing the manuscript. KD and YY contributed substantially to the conception and design of the study. YW, HX, XG revised it critically for important intellectual content. QL and CW contributed to data collection and follow up. SL, JL and JY made contribution to analysis and interpretation of data.

    • Funding This work was supported by CAMS Innovation Fund for Medical Sciences (CIFMS) (2016-I2M-1-009), the Twelfth Five-Year Planning Project of the Scientific and Technological Department of China (2011BAI11B02) and Fundamental Research Funds for the Central Universities (2018-F04).

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Ethics approval The China Acute Myocardial Infarction registry was approved by the Institutional Review Board Central Committee at Fuwai Hospital, Chinese Academy of Medical Sciences.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data availability statement Data are available upon reasonable request.