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Mortality and cause of death in South Korean patients with Parkinson’s disease: a longitudinal follow-up study using a national sample cohort
  1. Hyo Geun Choi1,2,
  2. Jae-Sung Lim3,
  3. Young Kyung Lee4,
  4. Songyong Sim5,
  5. Miyoung Kim4
  1. 1 Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Republic of Korea
  2. 2 Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, Republic of Korea
  3. 3 Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea
  4. 4 Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea
  5. 5 Department of Statistics, Hallym University, Chuncheon, Republic of Korea
  1. Correspondence to Professor Miyoung Kim; rabbit790622{at}


Objective The incidence rate of Parkinson’s disease (PD) is growing rapidly owing to the ageing population. We investigated the mortality rates and causes of death in South Korean patients with PD.

Design We investigated a national cohort using the nationwide insurance database.

Setting Korean Health Insurance Review and Assessment Service—National Sample Cohort database.

Participants We included 3510 participants ≥60 years of age who were diagnosed with PD between 2002 and 2013, as well as 14 040 matched controls.

Interventions None

Primary and secondary outcome measures A stratified Cox proportional hazards model was used to evaluate patients with PD who were matched 1:4 with non-PD control subjects adjusted for age, sex, income and region of residence. The causes of death were grouped into 12 classifications.

Results The adjusted HR for mortality in the PD group was 2.09 (95% CI 1.94 to 2.24, p<0.001). Subgroup analysis according to age (<70 years, 70–79 years, and ≥80 years) and sex revealed that patients with PD showed higher adjusted HRs for mortality across all subgroups. Mortalities caused by metabolic, mental, neurologic, circulatory, respiratory, and genitourinary diseases, as well as trauma, were more common in the PD group than in the control group, with the highest OR observed in patients with neurologic disease.

Conclusions We demonstrated that PD in South Korean patients ≥60 years of age was associated with increased mortality in both sexes regardless of age.

  • Parkinson’s disease
  • mortality
  • Korean

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  • SS and MK contributed equally.

  • Contributors HGC composed the manuscript, J-SL provided neurologists’ perspectives, YKL reviewed the result and SS and MK designed and supervised the study.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The ethics committee of Hallym University approved the use of these data (approval number 2014-I148).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement The data used for this study are available from the Korea National Health Insurance Sharing Service ( subject to their requirements and fees.

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