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Drug-induced sleep endoscopy compared with systematic adenotonsillectomy in the management of obstructive sleep apnoea in children: a systematic review and meta-analysis protocol
  1. Anne-Sophie Prévost1,
  2. Mathieu Hylands2,
  3. Mireille Gervais1,
  4. Jean-Paul Praud3,
  5. Marie-Claude Battista4,
  6. Stéphanie Déziel-Malouin5,
  7. Monia Lachance5,
  8. Francois Lamontagne6
  1. 1Division of Otorhinolaryngology—Head and Neck Surgery, Department of Surgery, Université de Sherbrooke, Sherbrooke, Quebec, Canada
  2. 2Division of General Surgery, Department of Surgery, Université de Sherbrooke, Sherbrooke, Quebec, Canada
  3. 3Division of Pediatric Pulmonology—Department of Pediatrics, Université de Sherbrooke, Sherbrooke, Quebec, Canada
  4. 4Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec, Canada
  5. 5Department of Anesthesia, Université de Sherbrooke, Sherbrooke, Quebec, Canada
  6. 6Department of Internal Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada
  1. Correspondence to Dr Anne-Sophie Prévost; anne-sophie.prevost{at}


Introduction Obstructive sleep apnoea affects up to 6% of children worldwide. Although current guidelines recommend systematic tonsillectomy and adenoidectomy, many children do not benefit from these interventions. Drug-induced sleep endoscopy (DISE) allows the dynamic evaluation of patients’ airways to identify the specific anatomic sites of obstruction. This intervention can potentially guide subsequent invasive procedures to optimise outcomes and minimise the number of children exposed to unnecessary operations.

Methods and analysis We will identify randomised controlled trials and controlled observational studies comparing DISE-directed interventions to systematic tonsillectomy and adenoidectomy in paediatric populations. We will search MEDLINE, EMBASE, CINAHL, CENTRAL as well as clinical trial registries and conference proceedings (initial electronic search date 9 October 2018). Screening, data extraction and risk of bias assessments will be performed in duplicate by independent reviewers. We will use the Grading of Recommendations Assessment, Development and Evaluation approach to assess the overall quality of evidence and present our results.

Ethics and dissemination Ethics approval is not required for this systematic review of published data. This review will be presented according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We will present our findings at otorhinolaryngology conferences and publish a report in a peer-reviewed journal.

PROSPERO registration number CRD42018085370.

  • paediatric otolaryngology
  • sleep medicine
  • anaesthesia in otolaryngology
  • paediatric anaesthesia
  • paediatric otolaryngology

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  • Contributors A-SP, MG, FL, M-CB, J-PP and MH conceived the research question. MH and FL conceptualised methodological analyses. A-SP and MH wrote the draft protocol and will review articles. All authors reviewed and approved the protocol and will contribute to the writing of the publication.

  • Funding This project is funded by the Département de chirurgie de l’Université de Sherbrooke.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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