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Pulmonary rehabilitation for pneumoconiosis: protocol for a systematic review and meta-analysis
  1. Hulei Zhao1,2,3,
  2. Yang Xie2,3,
  3. Jiajia Wang3,
  4. Xuanlin Li3,
  5. Jiansheng Li3
  1. 1 Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
  2. 2 Department of Respiratory Diseases, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China
  3. 3 Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, China
  1. Correspondence to Dr Yang Xie; xieyanghn{at}


Introduction Pneumoconiosis is characterised by diffuse fibrosis in lung tissue, and its incidence is on the rise. At present, there are limited therapeutic options for pneumoconiosis. Pulmonary rehabilitation (PR) has been widely used to treat pneumoconiosis,however, there is limited evidence concerning its efficacy. Therefore, we plan to conduct a systematic review to investigate the efficacy and safety of PR for pneumoconiosis.

Methods and analysis The following databases will be searched from their inception to 1 April 2019: PubMed, Embase, The Cochrane Library, Web of Science, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chongqing VIP and Wanfang Data. Randomised controlled trials of PR for pneumoconiosis will be included. Primary outcomes will include 6 min walk distance and St. George’s Respiratory Questionnaire. Study selection, extraction of data and assessment of study quality each will be independently undertaken. Statistical analysis will be conducted using Review Manager software.

Ethics and dissemination This systematic review will provide up-to-date information on PR for pneumoconiosis. The review does not require ethical approval and will be disseminated electronically through a peer-reviewed publication or conference presentations.

PROSPERO registration number CRD42018095266.

  • pulmonary rehabilitation
  • pneumoconiosis
  • systematic review and meta-analysis

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  • Contributors HZ drafted the protocol and will arbitrate any disagreements. YX and JL conceived the study and revised the manuscript. JW and XL will independently screen the potential studies, extract data from the included studies and assess the risk of bias. HZ will search the literature and conduct the data analysis. All authors have read and approved the final manuscript for publication.

  • Funding This work was supported by the Henan Province Priority and Advantage Discipline Construction Engineering Projects—Traditional Chinese Medicine (No.STS-ZYX-2017025); Program for Science and Technology Innovation Talents in Universities of Henan Province (No.19HASTIT008); National Public Welfare Industry Research Project-Traditional Chinese Medicine Industry (No.201507001-01); Special subject of Chinese medicine research of Henan Province (2018ZY1003).

  • Disclaimer The funder had no role in the development of the protocol.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This review does not require ethical approval.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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