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LASI-DAD study: a protocol for a prospective cohort study of late-life cognition and dementia in India
  1. Jinkook Lee1,
  2. Joyita Banerjee2,
  3. Pranali Yogiraj Khobragade1,
  4. Marco Angrisani1,
  5. A B Dey2
  1. 1 Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, USA
  2. 2 Geriatric Medicine, All India Institute of Medical Sciences, New Delhi, Delhi, India
  1. Correspondence to Dr. Jinkook Lee; jinkookl{at} and Professor A B Dey; abdey{at}


Introduction Alzheimer’s disease and related dementias can be considered the epidemic of the 21st century. Particularly, the predicted growth in the size of elderly populations in low-income and middle-income countries is expected to produce a dramatic surge in dementia prevalence and incidence. Although a rising burden of dementia presents an urgent challenge for India, previous efforts to study dementia in the country have relied on non-representative samples in geographically restricted regions. The Harmonised Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) will provide rich, population-representative data on late-life cognition and dementia and their risk factors for the first time in India.

Methods The LASI-DAD will recruit a sample of 3000 people aged 60+ years. Their family members or friends, whom respondents nominate as informants, participate in the computer-assisted personal interview. The study sample is drawn from the ongoing, nationally representative Longitudinal Aging Study in India, a multipurpose panel survey of aging. We aim to collect rich data on cognitive and neuropsychological tests, informant reports, and epidemiological data through a comprehensive geriatric assessment, and venous blood collection and assays. For a subsample, we collect neuroimaging data. Data collection is currently in progress in 14 States and Union Territories of India. Clinicians will provide clinical consensus diagnosis based on the Clinical Dementia Rating.

Ethics and dissemination Ethics approval was obtained from the Indian Council of Medical Research and all collaborating institutions. Anonymised data will be available for the larger research community through a secured website hosted by the Gateway to Global Aging Data platform. Research findings from the LASI-DAD team will be disseminated through journal publications and presentations at professional conferences.

  • cognition
  • dementia
  • cognitive impairment
  • elderly
  • india

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  • Contributors JL and ABD developed the overall research design protocol and gained funding. JL prepared the first draft. PYK and JB have been involved in all aspects of the study. MA developed a strategy for constructing sample weights. All authors substantially contributed and commented on the manuscript and approved the final version.

  • Funding This project is funded by the National Institute on Aging and the National Institutes of Health (R01 AG051125, 1RF1AG055273).

  • Competing interests None declared.

  • Ethics approval We obtained ethics approval from the Indian Council of Medical Research and all collaborating institutions, including the University of Southern California; the All India Institute of Medical Sciences, New Delhi; the International Institute for Population Sciences, Mumbai; All India Institute of Medical Sciences, Bhubaneswar; Dr SN Medical College, Jodhpur; Government Medical College, Thiruvananthapuram; Grant Medical College and JJ Hospital, Mumbai; Guwahati Medical College, Guwahati; Institute of Medical Sciences, BHU, Varanasi; Madras Medical College, Chennai; Medical College, Kolkata; National Institute of Mental Health and Neurosciences, Bengaluru; Nizam’s Institute of Medical Sciences, Hyderabad; and Sher-e-Kashmir Institute of Medical Sciences, Srinagar.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.