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Association between predialysis hypermagnesaemia and morbidity of uraemic restless legs syndrome in maintenance haemodialysis patients: a retrospective observational study in Zhejiang, China
  1. Yi Yang1,
  2. Hongying Ye1,2,
  3. Qien He1,3,
  4. Xiaohui Zhang1,4,
  5. Biying Yu5,
  6. Jingjuan Yang1,5,
  7. Jianghua Chen1
  1. 1Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
  2. 2Department of Nephrology, Jinhua Municipal Central Hospital, Jinhua, China
  3. 3Department of Nephrology, Beilun People’s Hospital, Ningbo, China
  4. 4Department of Nephrology, Yiwu Municipal Central Hospital, Yiwu, China
  5. 5Department of Nephrology, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu, China
  1. Correspondence to Dr Yi Yang; yangyixk{at}


Objective The aim of the present study was to determine whether the predialysis serum magnesium level was associated with morbidity of uraemic restless legs syndrome (RLS) in maintenance haemodialysis patients.

Design A retrospective observational study of morbidity of uraemic RLS was conducted.

Setting Patients on maintenance haemodialysis three times a week.

Participants We reviewed 578 patients receiving maintenance haemodialysis for >1 year as our cohort.

Outcome measures Uraemic RLS was diagnosed according to International RLS Study Group criteria, and hypermagnesaemia was defined as serum magnesium level >1.02 mmol/L.

Results The prevalence of uraemic RLS was 14.4% in our study cohort. Univariate analysis indicated that patients with uraemic RLS differed significantly from non-RLS ones in certain demographic and clinical characteristics, including younger age, longer dialysis duration, higher serum parathyroid hormone level and higher prevalence of predialysis hyperphosphataemia and hypermagnesaemia. Binary logistic-regression model analysis indicated that predialysis hypermagnesaemia was independently associated with uraemic RLS and conferred an increase in morbidity of the syndrome (OR=2.024; 95% CI 1.160 to 3.532; p=0.013). Moreover, we found that dialysis duration and predialysis hyperphosphataemia were independently associated with morbidity of uraemic RLS.

Conclusions Our data indicated that the predialysis serum magnesium level was associated with morbidity of uraemic RLS in maintenance haemodialysis patients and that predialysis hypermagnesaemia might serve as an independent risk factor for the syndrome.

  • uraemic restless legs syndrome
  • maintenance haemodialysis
  • magnesium
  • morbidity
  • predialysis

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  • Contributors YY participated in study design and wrote the manuscript. HY, QH, XZ and BY were involved in data acquisition. YY and JY analysed the data. JC supervised the study. Each author contributed important intellectual content during manuscript drafting or revision and accepts accountability for the overall work by ensuring that questions pertaining to the accuracy or integrity of any portion of the work are appropriately investigated and resolved.

  • Funding This work was supported by the grant from the National Nature Science Foundation of China (No.81670621) and the Nature Science Foundation of Zhejiang Province (No. LY16H050001).

  • Competing interests None declared.

  • Ethics approval The study was approved by the Institutional Ethics Committee of Zhejiang University, in accordance with the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The datasets used and analysed during the current study are available from the corresponding author on reasonable request.

  • Patient consent for publication Obtained.