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High prevalence of hyperuricaemia and its impact on non-valvular atrial fibrillation: the cross-sectional Guangzhou (China) Heart Study
  1. Wei-dong Lin1,
  2. Hai Deng1,
  3. Pi Guo2,
  4. Fang-zhou Liu1,
  5. Ru-yin Chen2,
  6. Xian-hong Fang1,
  7. Xian-zhang Zhan1,
  8. Hong-tao Liao1,
  9. Wen-xiang Huang1,
  10. Yang Liu1,
  11. Feng Wang1,
  12. Mu-rui Zheng3,
  13. Hua-zhang Liu3,
  14. Jun Huang1,
  15. Wei Wei1,
  16. Yu-mei Xue1,
  17. Shu-lin Wu1
  1. 1 Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Peoples Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
  2. 2 Department of Preventive Medicine, Shantou University Medical College, Shantou, China
  3. 3 Guangzhou Center for Disease Control and Prevention, Guangzhou, China
  1. Correspondence to Dr. Yu-mei Xue; xymgdci{at} and Professor Shu-lin Wu; drwushulin{at}


Objectives There are country and regional variations in the prevalence of hyperuricaemia (HUA). The prevalence of HUA and non-valvular atrial fibrillation (NVAF) in southern China is unknown.

Design A cross-sectional study.

Setting and participants A total of 11 488 permanent residents aged 35 or older from urban and rural areas of Guangzhou, China were enrolled. A questionnaire was used to compile each participant’s demographic information and relevant epidemiological factors for HUA and NVAF. All participants were assessed using a panel of blood tests and single-lead 24-hour ECG.

Main outcome measures HUA was defined as serum uric acid level >420 μmol/L in men and >360 μmol/L in women. NVAF was diagnosed as per guidelines.

Results The prevalence of HUA was 39.6% (44.8% in men and 36.7% in women), and 144 residents (1.25%) had NVAF. Prevalence of HUA increased with age in women but remained stably high in men. After adjusting for potential confounders, age, living in urban areas, alcohol consumption, central obesity, elevated fasting plasma glucose level, elevated blood pressure, lower high-density lipoprotein cholesterol level and elevated triglycerides level were associated with increased risk of HUA. Residents with HUA were at higher risk for NVAF. Serum uric acid level had a modest predictive value for NVAF in women but not men.

Conclusions HUA was highly prevalent among citizens of southern China and was a predictor of NVAF among women.

  • cardiac epidemiology
  • epidemiology
  • cardiology

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  • W-dL and HD contributed equally.

  • Contributors W-dL, HD, YX and S-lW conceived the study, analysed data, interpreted results and drafted the manuscript. PG, RC, FL, XF, XZ, HoL, WH, YL, FW, MZ, HuL, JH and WW collected data and completed the survey.

  • Funding This work was supported by National Natural Science Foundation of China (No. 81370295), Guangzhou Science and Technology Project (No. 201508020261 and No. 2014Y200196), Science and Technology Program of Guangdong Province, China (No. 2017A020215054) and Science and Technology Planning of Guangzhou City, China (No. 2014B070705005).

  • Competing interests None declared.

  • Ethics approval This study was approved by the Guangzhou Medical Ethics Committee of the Chinese Medical Association (No. GDREC2015306H) and was conducted in accordance with the ethical standards of the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The data are available from the corresponding author upon reasonable request.

  • Patient consent for publication Obtained.

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