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Prevalence and distribution of HPV types in genital warts in Xi’an, China: a prospective study
  1. Cansheng Zhu1,
  2. Yaofei Wang2,
  3. Weihua Mao1,
  4. Hongshan Zhang3,
  5. Jiaju Ma3
  1. 1Department of STD Laboratory, Shaanxi Provincial Institute for Skin Disease and STD Control, Xi’an, China
  2. 2Department of STD Control, Shaanxi Provincial Institute for Skin Disease and STD Control, Xi’an, China
  3. 3Department of Urology, Shaanxi Provincial Institute for Skin Disease and STD Control, Xi’an, China
  1. Correspondence to Dr. Cansheng Zhu; zhucansheng{at}163.com and Dr Yaofei Wang; wangyaofei2017{at}163.com

Abstract

Objectives To characterise the prevalence and distribution of human papillomavirus (HPV) types in genital warts in Xi’an, China.

Methods This prospective study was conducted in Shaanxi Provincial Institute for Skin Disease and STD Control (SPISSC) between September 2014 and April 2017. Genital wart samples were obtained from 879 patients, including 512 men and 367 women. HPV genotyping was performed by using an automatic nucleic acid hybridisation system.

Results Of the 879 patients with genital warts, the detectable rates of low-risk, high-risk and total HPV types were 45.4%, 34.5% and 57.8%, respectively. The detectable rate of low-risk HPV types (45.4%) was significantly higher than that of high-risk HPV types (34.5%) (χ2=21.85, p<0.01). The detectable rate of low-risk HPV types of men (52.3%) was significantly higher than that of women (35.7%) (χ2=23.90, p<0.01). The detectable rates of one HPV type infection and two and three or more HPV type coinfections were 26.1%, 17.5% and 14.2%, respectively. HPV6 (24.9%), HPV11 (17.9%), HPV52 (9.9%) and HPV16 (7.3%) were the four most common HPV types.

Conclusions The results of this study suggest that low-risk HPV types are major pathogens of genital warts, but high-risk HPV type infections and multiple HPV type coinfections are also common in genital warts. HPV6, 11, 52 and 16 are the four most common HPV types in genital wart in Xi’an, China.

  • epidemiology
  • diagnostic microbiology
  • public health
  • virology

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Footnotes

  • Contributors CZ and YW designed this study and analyzed data. WM collected specimens and detected HPV types. HZ and JM performed clinical diagnosis of genital warts. CZ drafted the paper. All authors approved the final version of the article.

  • Funding This research was supported by the Shaanxi Science and Technology Research and Development Program (grant number 2014K11-02-03-10).

  • Competing interests None declared.

  • Ethics approval The Ethics Committee of SPISSC approved the collection of specimens of genital warts and testing of the HPV types in the specimens (approval number: SXEDC2017-001).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

  • Patient consent for publication Obtained.

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