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Impact of maternal smoking on early childhood health: a retrospective cohort linked dataset analysis of 697 003 children born in Scotland 1997–2009
  1. Richard Lawder1,
  2. Bruce Whyte2,
  3. Rachael Wood1,3,
  4. Colin Fischbacher1,
  5. David Michael Tappin4
  1. 1 Information Services Division, NHS National Services Scotland, Edinburgh, UK
  2. 2 Glasgow Centre for Population Health, University of Glasgow, Glasgow, UK
  3. 3 Child Life and Health, University of Edinburgh, Edinburgh, UK
  4. 4 Scottish Cot Death Trust, 5th Floor, West Glasgow Ambulatory Care Hospital, University of Glasgow, Glasgow, UK
  1. Correspondence to Dr David Michael Tappin; david.tappin{at}glasgow.ac.uk

Abstract

Objective Smoking during pregnancy is associated with adverse health impacts on mother and child. We used a large linked Scottish dataset to produce contemporary estimates of the impact on child health, particularly hospitalisation.

Design Retrospective cohort study linking birth, death, maternity, infant health, child health surveillance and admission records. We examined the association between smoking status at maternity booking and pregnancy outcomes, hospital admission and death during the first 5 years of life. Models were adjusted for maternal age, socioeconomic status, infant feeding, country of birth, sex, parity and delivery mode. We calculated population attributable fraction (PAF) for each outcome.

Setting Scotland, UK.

Participants Singleton births between 1997 and 2009 (n=697 003) followed to March 2012.

Results 332 386 children had at least one admission by 31 March 2012. There were 56 588 born small for gestational age, 40 492 prematurely and 1074 postneonatal deaths. Within the first 5 years of life, 56 615 children had at least one admission for acute respiratory infections, 24 088 for bronchiolitis and 7549 for asthma. Maternal smoking significantly increased admission for acute respiratory infections (adjusted HR 1.29, 95% CI 1.25 to 1.34, PAF 6.7%) and bronchiolitis (HR 1.43, 95% CI 1.38 to 1.48 under 1 year, PAF 10.1%), asthma (HR 1.29, 95% CI 1.22 to 1.37 age 1–5 years, PAF 7.1%) and bacterial meningitis (HR 1.49, 95% CI 1.30 to 1.71, PAF 11.8%) age 0–5 years. Neonatal mortality (adjusted OR 1.32, 95% CI 1.17 to 1.49, PAF 6.7%), postneonatal mortality (OR 2.18, 95% CI 1.87 to 2.53, PAF 22.3%), small for gestational age (OR 2.67, 95% CI 2.62 to 2.73, PAF 27.5%) and prematurity (OR 1.41, 95% CI 1.37 to 1.44, PAF 8.8%) were higher among the offspring of smokers.

Conclusion Smoking during pregnancy causes significant ill health and death among children born in Scotland. These findings support continued investment to reduce smoking among women before, during and after pregnancy as 50% of women will go on to have further children.

  • pregnancy
  • smoking
  • pregnancy outcome
  • infant death
  • infant, small for gestational age
  • child health

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Footnotes

  • Contributors All authors helped plan this study. RL analysed the data and commented on the manuscript drafts. CF supervised RL and commented on the manuscript drafts. DMT wrote the manuscript. BW commented on the manuscript drafts and helped create the database. RW commented on the manuscript drafts.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional unpublished data are available from the study.

  • Author note Technical appendix, statistical code and dataset available from: Information Services Division NHS National Services Scotland, Edinburgh, Scotland.

  • Patient consent for publication Not required.

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