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Kanagawa Investigation of the Total Check-up Data from the National database (KITCHEN): protocol for data-driven population-based repeated cross-sectional and 6-year cohort studies
  1. Kei Nakajima1,2,
  2. Taizo Iwane1,
  3. Ryoko Higuchi1,
  4. Michi Shibata1,3,
  5. Kento Takada1,
  6. Jun Uda4,
  7. Mami Anan1,
  8. Michiko Sugiyama1,
  9. Teiji Nakamura1
  1. 1 School of Nutrition and Dietetics, Faculty of Health and Social Services, Kanagawa University of Human Services, Yokosuka, Japan
  2. 2 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
  3. 3 Department of nutrition, St. Marianna University School of Medicine, Kawasaki, Japan
  4. 4 Graduate School of Health Care Sciences, Jikei Institute, Osaka-shi, Japan
  1. Correspondence to Professor Kei Nakajima; nakajima-rsh{at}kuhs.ac.jp

Abstract

Introduction The unmitigated incidence of cardiometabolic diseases, such as type 2 diabetes and metabolic syndrome, has gained attention in Japan. ‘Big data’ can be useful to clarify conflicting observations obtained from studies with small samples and about rare conditions that are often neglected. We epidemiologically address these issues using data from health check-ups conducted in Kanagawa Prefecture, the prefecture with the second largest population in Japan, in the Kanagawa Investigation of the Total Check-up Data from the National Database (KITCHEN).

Methods and analysis This research consists of a series of population-based cross-sectional studies repeated from 2008–2014 and 6-year cohort studies. Since 2017, we have reviewed the data of people living in Kanagawa Prefecture who underwent a health check-up mainly for general health and the prevention of metabolic syndrome. The sample size ranges from 1.2 million to 1.8 million people in the cross-sectional studies and from 370 000 to 590 000 people in the cohort studies. These are people aged 40–74 years, whose clinical parameters were measured and who responded individually to a questionnaire. We investigate potential associations and causalities of various aetiologies, including diabetes and metabolic syndrome, using clinical data and lifestyle information. With multidisciplinary analysis, including data-driven analysis, we expect to obtain a wide range of novel findings, to confirm indeterminate previous findings, especially in terms of cardiometabolic disease, and to provide new perspectives for human health promotion and disease prevention.

Ethics and dissemination Ethical approval was received from the Ethics Committee of Kanagawa University of Human Services (10-43). The protocol was approved in December 2016 by the Japanese Ministry of Health, Labour and Welfare (No. 121). The study results will be disseminated through open platforms including journal articles, relevant conferences and seminar presentations.

  • epidemiology
  • general medicine (see internal medicine)
  • geriatric medicine
  • public health

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Footnotes

  • Contributors KN, TI, KT, JU, MSu and TN contributed to the study design, the interpretation of the initial analysis or the discussion of the literature and expected results. KN, TI, MSh, RH and MA have conducted the data analysis. KN prepared the first draft of the manuscript, and all authors read and edited the manuscript.

  • Funding This work was partly supported by a special Grant of Kanagawa University of Human Services, which was determined on 12 June 2017, and Kanagawa Prefecture (No. 505744).

  • Competing interests None declared.

  • Ethics approval Study protocol was approved by the ethics committee of Kanagawa University of Human Services (10-43).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.