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I have read your study with interest. May I raise an interesting point you may wish to investigate? I have been researching curious international patterns of on/off switching in deaths and medical admissions. When looking at Australian data I noted that switch-on seemed to correspond with the reported incidence of GP consultation for Herpes Zoster, i.e. switch-on may have reactivated Herpes infections. More details of this research are available at http://www.hcaf.biz/2010/Publications_Full.pdf - I hope that this is useful to your research.