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Mental health
Protocol
Early intervention services for non-psychotic mental health disorders: a scoping review protocol
  1. Katie Richards1,
  2. Amelia Austin1,
  3. Karina Allen1,2,3,
  4. Ulrike Schmidt1,2
  1. 1 Psychological Medicine, King's College London, London, UK
  2. 2 Eating Disorder Outpatients Service, South London and Maudsley Mental Health NHS Trust, London, UK
  3. 3 School of Psychological Science, The University of Western Australia, Perth, Western Australia, Australia
  1. Correspondence to Katie Richards; katie.richards{at}kcl.ac.uk

Abstract

Introduction Worldwide mental health disorders are associated with a considerable amount of human suffering, disability and mortality. Yet, the provision of rapid evidence-based care to mitigate the human and economic costs of these disorders is limited. The greatest progress in developing and delivering early intervention services has occurred within psychosis. There is now growing support for and calls to extend such approaches to other diagnostic groups. The aim of this scoping review is to systematically map the emerging literature on early intervention services for non-psychotic mental health disorders, with a focus on outlining how services are structured, implemented and scaled.

Methods and analysis The protocol was developed using the guidance for scoping reviews in the Joanna Briggs Institute manual and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews checklist. A systematic search for published and unpublished literature will be conducted using the following databases: (1) MEDLINE, (2) PsycINFO, (3) HMIC, (4) EMBASE and (5) ProQuest. To be included, documents must describe and/or evaluate an early intervention service for adolescents or adults with a non-psychotic mental health disorder. There will be no restrictions on publication type, study design and date. Title and abstract, and full-text screening will be completed by one reviewer, with a proportion of articles screened in duplicate. Data analysis will primarily involve a qualitatively summary of the early intervention literature, the characteristics of early intervention services and key findings relating to their evaluation and implementation.

Ethics and dissemination The synthesis of published and unpublished articles will not require ethical approval. The results of this scoping review will be published in a peer-reviewed journal and disseminated via social media, conference presentations and other knowledge translation activities.

  • early intervention
  • implementation
  • mental health
  • health service design

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

https://doi.org/10.1136/bmjopen-2019-033656

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    Strengths and limitations of this study

    • This scoping review will provide a comprehensive overview of both published and unpublished literature for the emerging research field of early intervention services for non-psychotic mental health disorders.

    • The review will be conducted according to the standardised methodology outlined in the Joanna Briggs Institute manual and using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist for scoping reviews.

    • Part of the screening and charting process will be completed in duplicate to ensure reliability of these methods.

    • Only articles written in English, German, French and Spanish will be included, the review may, therefore, be biassed.

    Introduction

    Early intervention is widely perceived as beneficial in medicine and refers to the early detection and initiation of stage-specific treatment.1 Proactive treatments matched to the stage of illness can limit or even avert unfavourable outcomes, reducing the need for costly and more invasive treatments in the future.2 3 Despite such promise, early intervention approaches have been slow to gain momentum in mental health.4 5 Mental illnesses are a major contributor to mortality and disability worldwide, particularly for young people.6–8 The typical age of onset for mental disorders is adolescence and early adulthood (12–30 years), a period of marked social, psychological and biological change.9 10 A delay in or lack of access to effective treatments during this time could disrupt key developmental milestones and have long-lasting effects on health, social and occupational trajectories.11

    Service provision does not match the topography of onset or burden of disease associated with mental disorders, even in relatively well-developed health systems.12 Globally, access to evidence-based care is poor, and even for those that do access it, this is often after lengthy delays.13–15 The duration of untreated illness (DUI), defined as the period between the onset of psychiatric disorder and the initiation of treatment, ranges from 1 to 2 years for psychosis to 10 years for obsessive–compulsive disorder (OCD).16–19 Over time, mental disorders can become more entrenched through functional deterioration, neuroadaptation and habitual behaviour patterns.20–23 Indeed, a longer DUI is associated with worse symptomatic and functional outcomes, and a lower treatment response across diagnostic groups.19 24–27 More worryingly, young people, the group at highest risk for psychiatric difficulties, tend to have the worst access to timely care.13 18 28–30

    Together, such findings provide a compelling case for establishing early intervention services that match the developmental needs and symptomatic profile of individuals with recent-onset mental disorders.4 14 The greatest strides in early intervention have been made within psychosis. Over the past 30 years, early intervention for psychosis (EIP) has gained tremendous support from researchers and healthcare professionals worldwide.14 EIP services have two fundamental aims: to reduce the duration of untreated psychosis, and to provide evidence-based, stage-specific treatment.31 EIP services use a clinical staging approach to map the extent of illness progression from early presymptomatic risk to severe and enduring, enabling a prevention orientated framework that matches the intensity of treatment to the level of need.32 33 A comprehensive body of high-quality research shows that compared with standard care, multicomponent EIP services are associated with a reduction in symptom severity, relapse rates and hospitalisation risk, as well as improved global functioning and quality of life.34 Moreover, consistent evidence suggests that EIP services are a cost-effective alternative to standard care.35 There has been a recent surge in papers calling for early intervention approaches to be broadened to other diagnostic groups, including major depression,36 OCD,22 eating disorders37 and bipolar disorder.38 Preliminary evidence from services for recent-onset eating and mood disorders demonstrate significant improvements in symptoms, reduced hospital (re)admissions, and most importantly, high levels of patient satisfaction.39–42

    The utility of focusing exclusively on discrete diagnostic categories in the delivery of early intervention specifically, and mental healthcare more generally has, however, been questioned.32 43 The early stages of mental disorder are often characterised by fluctuating patterns of specific and non-specific subthreshold symptoms, diagnostic instability and comorbidity.44 45 A single-disorder focus could result in these earlier presentations of illness being excluded.46 A transdiagnostic approach, consistent with evidence for pluripotent models of clinical staging, has been put forward as a necessary solution to address this problem.32 43 47 48 The recognition of the need to broaden the early intervention paradigm has led to the development of several integrated youth mental health hubs.49 50 These hubs act as entry-level services for young people irrespective of diagnosis, and typically provide a comprehensive package of low-intensity mental, physical and social care support in community settings. Young people tend to rate these services positively and between 52% and 68% experience improvements in symptoms and functioning. However, a proportion of individuals with more severe symptoms do not seem to benefit from these services and rigorous outcome research for youth hubs is limited.50 51

    Although the role of early intervention in reducing distress and functional impairment seems obvious, the evidence-base for these services is incomplete and much more work needs to be done.14 22 There is limited prospective evidence evaluating the utility of these services for non-psychotic disorders, it is unclear to what extent the findings from psychosis would translate to other diagnostic groups. There is also a lack of research evaluating the feasibility or the implementation processes of services in clinical settings.51 Moreover, even within psychosis, further research is needed to determine how long EIP services should be provided, whether it is the reduction in DUI or other components of EIP services that account for the improved outcomes, and whether outcomes would be similar with other service structures and models.52 53 An ever-growing population, accompanied by reducing health budgets, creates an environment where only services that demonstrate effectiveness, economic viability and sustainability receive funding.54 It is, therefore, imperative to develop a rigorous evidence base to refine, adapt and evaluate early intervention services for non-psychotic disorders, with a particular focus on identifying the "active ingredients” of such services and the most effective methods for widespread scaling and implementation.

    The primary objective of this review is to provide a baseline characterisation of the differing ways in which early intervention services are structured and implemented for non-psychotic mental health disorders. The emerging literature for non-psychotic disorders is heterogeneous and dispersed, with distinct streams of research developing in disciplinary silos. The aim of this review is to draw together these streams to facilitate collaboration and cross-disciplinary learning and discourse. By synthesising the field and highlighting commonalities and differences, we hope that a broad set of common principles for early intervention services will emerge. This review, in conjunction with reviews in psychosis, will help set the stage for a more unified approach to expanding and refining early intervention services for psychiatric disorders. Here, we focus exclusively on disorders that tend to emerge in adolescence and adulthood rather than in childhood. Neurodevelopmental disorders typically use a very different approach to early intervention than adolescent-onset and adult-onset disorders (eg, intervening in infancy).55 A scoping review methodology was selected for this review as early intervention is an emerging, dispersed and heterogeneous research area and is therefore not amenable to the narrower aims of a traditional systematic review.56 57 Given that this is a relatively new research area, we sought to map all the available evidence within this field rather than only the best available evidence (eg, randomised controlled trials).58

    Research questions

    1. What is the extent, range and nature of the literature on early intervention services for adolescents and adults with non-psychotic mental health disorders?

    2. What are the characteristics of early intervention services and care pathways?

      1. Are there any similarities and/or differences across early intervention services provided for each diagnosis and transdiagnostically?

    3. Are there any factors that influence the implementation of early intervention services (ie, barriers and facilitators to implementation)?

    4. Do early intervention services reduce DUI, improve the course and outcome of mental disorders or minimise the disruption to psychosocial development and function?

    Methods and analysis

    The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR) checklist,57 and the scoping review framework outlined in the Joanna Briggs Institute (JBI) Reviewer’s Manual59 were used to guide the development of this protocol.

    Eligibility criteria

    Documents will be included if they: (1) Describe and/or evaluate an early intervention service for non-psychotic mental health disorders (concept) based in any type of healthcare facility (ie, hospitals, day services and community settings) and in any geographical area (context). Here, early intervention refers to a structured programme of care delivered by a stand-alone team or teams integrated into mental health services that provide treatment for individuals with recent-onset subthreshold or threshold disorders. The level of care can vary from low-intensity techniques of signposting, psychoeducation and self-help resources all the way through to specialised multidisciplinary teams and complex high intensity interventions; (2) Describe and/or evaluate an early intervention service for adolescents (≥10–17 years) or adults (>18 years) with a recent-onset subthreshold or threshold mood disorder, anxiety disorder, eating disorder, personality disorder, impulse control or substance use disorder, and/or somatoform disorder (types of participants). Transdiagnostic early intervention services and early intervention services for comorbid/concurrent disorders will be included provided that at least one of the diagnoses is listed in the previous sentence; (3) Mixed child and adolescent services will be included, where feasible, only information relevant for the adolescent portion of the services will be charted and (4) All document types and study designs are eligible for inclusion: randomised controlled trials, non-randomised studies, observational studies, qualitative studies, reviews, ongoing trials, protocols, theoretical papers, grey literature, editorials, opinions pieces and expert consensus statements (types of studies).

    Documents will be excluded if they: (1) Describe a primary prevention programme based in educational establishments, high-risk groups (eg, athletes) or in the general population, (2) Describe a parent-only intervention, (3) Describe a specific intervention (eg, type of cognitive–behavioural therapy) that is not attached to a service and (4) Primarily or only focus on early intervention for a physiological or medical condition, schizophrenia spectrum and other psychotic disorders and/or neurodevelopmental disorders.

    Search strategy

    A comprehensive literature search will be conducted from inception on PsycINFO, MEDLINE, EMBASE and HMIC. ProQuest databases will also be searched for grey literature (ie, conference papers and proceedings, theses, government publications). The search is completed in three stages. First, an initial limited search was conducted in MEDLINE using the terms “early intervention” and “mood disorder” or “anxiety disorder” or “eating disorder” or “personality disorder” or “impulse control disorder” or “substance use disorder” or “somatoform disorder”. The initial limited search was conducted by KR in April 2019 to identify keywords and subject headings to generate a search strategy. Different combinations of keywords and subject headings were trialled in MEDLINE, and key papers from the early intervention field were used as indicators for the sensitivity of the search strategy. The preliminary search strategy was developed by KR and reviewed by AA, KA and US. An iterative process was used to balance the sensitivity and specificity. The MEDLINE-specific search strategy returns 3545 documents before deduplication and is outlined in table 1.

    View this table:
    Table 1

    MEDLINE search strategy

    In the second stage, all databases will be searched using the MEDLINE search strategy. The search strategy will be tailored to each database. The search for scoping reviews are more iterative than systematic reviews, it is; therefore, feasible that as the reviewers become more familiar with the literature that additional search terms and sources may be identified. The final stage involves identifying additional articles by searching the reference lists of included articles. Studies not reported in English, German, French and Spanish will be excluded from the review during the screening and eligibility assessment. No date limits will be applied to the search. References will be imported to the EndNote X8 reference manager.

    Study selection process

    The title and abstract screening in the second stage of the search will be completed by one reviewer with a portion of the articles being screened in duplicate to ensure reliability (25%). Retrieved full texts will also be screened by one reviewer with a sample of full-text documents (25%) being screened in duplicate for reliability. The eligibility criteria will be applied to each document on a case-by-case basis to determine eligibility for inclusion. Discrepancies between reviewers will be resolved by discussion and if necessary other members of the review team will be consulted.

    Data items and charting

    A standardised data charting form developed by the study team will be used to chart the data from eligible studies (see table 2 for a description of each data item). The data charting form was developed using the template from the JBI manual and by drawing on recent reviews of youth service models.50 51 Each section of the data charting form was developed to address one of the four research questions. The ‘Document Details’ section which provides descriptive information on document type, author(s), publication date, title and aim/purpose of document will be used to evaluate the extent, nature and range of the literature on early intervention services (question 1). The second section ‘Characteristics of Early Intervention Service’ will address the second question as key characteristics of the services, namely the population, setting, structure and interventions used in early intervention services will be charted (question 2). The ‘Outcome Research’ section will be used to answer questions 3 and 4 as any data related to implementation, effectiveness or efficacy will be charted (question 3 and 4). Similar to the full-text screening, one reviewer will chart the majority of the documents with only a portion (25%) of the documents being charted in duplicate to ensure reliability. A small selection of documents will be charted by both reviewers at the outset to ensure that there is clarity and consistency in the use of the data charting form. Where there is more than one paper on the same service model, information will be pooled across the papers to provide the most detailed description of the model and any available evidence.

    View this table:
    Table 2

    Draft data charting form

    Critical appraisal

    The lack of critical appraisal tools in scoping reviews has been highlighted as one of the primary limitations of this knowledge synthesis method.60 Critical appraisal can facilitate the interpretation of reviews by identifying the relative strengths and weaknesses of the included articles and identifying gaps in the research field. However, formal evaluations of methodological quality for scoping reviews can be challenging given the diversity of study designs and the volume of included literature.61 Given the range of study designs, a two-stage assessment of methodological quality will be conducted for this review. First, each study will be ranked using the JBI Levels of Evidence for Effectiveness from high (level 1) to low (level 5) (level 1—Experimental Designs; level 2—Quasi-experimental Designs; level 3—Observational–Analytical; level 4—Observational–Descriptive; level 5—Expert Opinion and Bench Research).62 Once stratified according to the level of evidence, the quality of the studies within each stratum will be evaluated using the JBI Critical Appraisal tools.63 Additionally, the generalisability and real-world applicability (external validity) of the included studies will be evaluated against the domains of the reach, effectiveness, adoption, implementation and maintenance (RE-AIM) framework. A modified version of a RE-AIM framework rating system developed by Gaglio et al will be used in the current study.64 The modified rating system can be seen in table 3. Each document will be given a rating ranging from 1 (limited generalisability or no information) to 3 (generalisable/pragmatic or information to enable generalisation) on six key domains: participant representativeness, setting representativeness, outcome representativeness, fidelity/adaptation, cost/feasibility of intervention and sustainment. A narrative summary of the methodological quality will be provided alongside quantitative values for each domain of the RE-AIM framework. A portion of the included articles will be appraised in duplicate.

    View this table:
    Table 3

    Summary of reach, effectiveness, adoption, implementation and maintenance framework criteria

    Synthesis of results

    The search results will be reported using a flow diagram to clearly detail the review decision process, indicating the number of citations screened, duplicates removed, study selection and full texts retrieved. The characteristics of the included studies will be presented in an informative table with a narrative and quantitative (eg, frequencies) summary in text. Figures will be used to display the distribution of documents over time and across diagnoses. Descriptions of the early intervention services will be reported for each diagnostic group and transdiagnostically along with any evidence supporting the services and barriers and facilitators to implementation. An aggregated summary of early intervention services with descriptions of common themes and differences across the services will be provided. An effort will be made to identify gaps in knowledge to inform the direction of future research.

    Patient and public involvement

    No patients or public were involved in the development of this protocol.

    Dissemination

    This review contributes to the growing body of research for early intervention initiatives in mental health by mapping the existing literature on early intervention services for non-psychotic mental health disorders. Through the publication of the results and dissemination via social media and conference presentations, the results will hopefully provide a timely foundation for cross-disciplinary discourse and early intervention service development and research. The results of this review may inform the design of new services and policies to support them.

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    Footnotes

    • Twitter @krichar25, @Ame_Austin

    • Contributors All authors contributed to the development of this protocol. KR drafted the manuscript and search strategy. AA, KA and US reviewed the search strategy and the draft manuscripts. KR incorporated the feedback from the authors. All authors read and approved the final manuscript.

    • Funding KR and AA are supported by the Health Foundation Scaling Up programme. US is supported by a National Institute of Health Research (NIHR) Senior Investigator Award and receives salary support from the NIHR Mental Health Biomedical Research Centre at the South London and Maudsley NHS Foundation Trust and King’s College London. KA is supported by the NHS Innovation Accelerator programme.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Ethics approval The synthesis of existing knowledge will not require ethical approval.

    • Provenance and peer review Not commissioned; externally peer reviewed.