Objective To identify factors that influence general practitioners’ (GPs’) oral antibiotic prescribing for acute respiratory tract complaints (aRTCs) in Malta.
Design Repeated, cross-sectional surveillance.
Setting Maltese general practice; both public health centres and private GP clinics.
Participants 30 GPs registered on the Malta Medical Council’s Specialist Register and 3 GP trainees registered data of 4831 patients of all ages suffering from any aRTC. Data were collected monthly between May 2015 and April 2016 during predetermined 1-week periods.
Outcome measures The outcome of interest was antibiotic prescription (yes/no), defined as an oral antibiotic prescription issued for an aRTC during an in-person consultation, irrespective of the number of antibiotics given. The association between GP, practice and consultation-level factors, patient sociodemographic factors and patient health status factors, and antibiotic prescription was investigated.
Results The antibiotic prescription rate was 45.0%. Independent factors positively associated with antibiotic prescribing included female GP sex (OR 2.3, 95% CI 1.22 to 4.26), GP age with GPs ≥60 being the most likely (OR 34.7, 95% CI 14.14 to 84.98), patient age with patients ≥65 being the most likely (OR 2.3, 95% CI 1.71 to 3.18), number of signs and/or symptoms with patients having ≥4 being the most likely (OR 9.6, 95% CI 5.78 to 15.99), fever (OR 2.6, 95% CI 2.08 to 3.26), productive cough (OR 1.3, 95% CI 1.03 to 1.61), otalgia (OR 1.3, 95% CI 1.01 to 1.76), tender cervical nodes (OR 2.2, 95% CI 1.57 to 3.05), regular clients (OR 1.3, 95% CI 1.05 to 1.66), antibiotic requests (OR 4.8, 95% CI 2.52 to 8.99) and smoking (OR 1.4, 95% CI 1.13 to 1.71). Conversely, patients with non-productive cough (OR 0.3, 95% CI 0.26 to 0.41), sore throat (OR 0.6, 95% CI 0.53 to 0.78), rhinorrhoea (OR 0.3, 95% CI 0.23 to 0.36) or dyspnoea (OR 0.6, 95% CI 0.41 to 0.83) were less likely to receive an antibiotic prescription.
Conclusion Antibiotic prescribing for aRTCs was high and influenced by a number of factors. Potentially inappropriate prescribing in primary care can be addressed through multifaceted interventions addressing modifiable factors associated with prescription.
Trial registration number NCT03218930
- primary care
- respiratory infections
- antibiotic prescribing
- general practitioners
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Strengths and limitations of this study
This is the first study in Malta that looks at factors influencing antibiotic prescribing using repeated cross-sectional surveillance data.
The simple to complete surveillance forms were intended to aid documentation of as many acute respiratory tract complaint cases as possible, while reducing general practitioner (GP) drop-outs and non-reporting. Given its design and incorporation into clinical practice, it may have helped to reduce the effect of observation bias.
GP participation was voluntarily; therefore, it is possible that the GP sample consists of GPs who were more interested in the research area or more conservative prescribers than non-participating GPs, affecting the study’s representativeness.
The audit-based nature of the study may have resulted in measurement error; GPs may have completed patient background information themselves without directly asking the patient and variables located at the end of the surveillance sheet that were left unmarked may have been inaccurately assumed to be non-cases.
Since GPs were issued 3 monthly feedback reports, a behavioural change intervention itself, their antibiotic prescribing rate may have been affected as a result.
Since their discovery, antibiotics have saved lives and reduced suffering; however, their considerable overuse and misuse has, in part, led to the development of antibiotic resistance, threatening their effectiveness globally. Unchecked, antibiotic resistance can halt and potentially reverse decades of medical progress, with severe repercussions on patient outcomes and healthcare expenditure both on an individual and societal level.1 Antibiotics do not only target pathogenic bacteria; their use has long-lasting effects on gut flora and has been shown to be associated with allergy development and metabolic syndromes for example, particularly when prescribed during infancy.2
In Europe, a positive correlation between antibiotic use and resistance has been shown.3 Most antibiotic prescriptions are provided in outpatient care, with respiratory tract infections being the most common diagnoses.3 Studies have shown that up to 78% of patients are prescribed antibiotics for respiratory tract infections in primary care, even though an estimated 90% are viral in aetiology and thus antibiotics are seldom required.4–8 Indeed, unless pneumonia is suspected, the effect of antibiotic treatment is moderate at best indicating that many antibiotic prescriptions are provided unnecessarily and without any overall patient benefit.9 Consequently, a key strategy to contain antibiotic resistance is to improve antibiotic use in primary care, particularly among general practitioners (GPs).
While primary care guidelines often recommend limited antibiotic use in the treatment of respiratory tract infections, substantial variation exists in practical case management across countries and the evidence of over-prescribing is abundant.7 10 11 The decision to prescribe an antibiotic is complex and influenced by a host of interconnected factors including, but not limited to, provider attitudes and characteristics, patient age, comorbidities, signs and symptoms, expectations, environmental and cultural factors.10 12–15 Further cloaked by diagnostic uncertainty, GPs risk misdiagnosing and misclassifying the aetiology of respiratory tract infections, and may prescribe antibiotics to be on the safe side.
In the latest Special Eurobarometer survey on antibiotic resistance held in 2018, Malta reported the second highest antibiotic consumption in Europe with 42% of Maltese respondents reporting taking at least one antibiotic course in a calendar year.16 Non-prescribed use was minimal at 4%.16 Our recently published descriptive study based on surveillance data showed that, in 2015/2016, 46% of patients with acute respiratory tract complaints (aRTCs) were prescribed antibiotics by their GP.5 The top three diagnoses that received an antibiotic prescription were tonsillitis (96%), otitis media (93%) and bronchitis (88%), and the most commonly prescribed antibiotics were macrolides (36%) and penicillins with a β-lactamase inhibitor (33%).5 Indeed, the majority of antibiotic consumption in Malta occurs in the community and comprises primarily broad-spectrum antibiotics (ie, tetracyclines, beta-lactam antibacterials, second-generation and third-generation cephalosporins, macrolides and fluoroquinolones).5 17 18
Nationwide data on antibiotic prescribing in Maltese primary care are lacking and Malta has only been able to provide the European Surveillance of Antimicrobial Consumption Network (ESAC-Net) with wholesale distributor data to estimate community antibiotic use. As a result, it has not been possible to run in-depth analysis to elucidate factors that impact antibiotic prescribing. Recognising the need to identify and understand the drivers of antibiotic prescribing in primary care to develop targeted antibiotic stewardship activities and improve their chance of success, we decided to carry a more in-depth analysis of our 2015/2016 surveillance data. Therefore, this study aimed to identify factors that influence GPs’ oral antibiotic prescribing for aRTCs in Malta.
Study design, setting and participants
This cross-sectional surveillance study provided baseline data for the Maltese Antibiotic Stewardship Programme in the Community (MASPIC) project, a quasi-experimental social marketing intervention aiming to reduce inappropriate antibiotic prescribing in Maltese primary care. A study protocol with a detailed description of the study setting and design has already been published.19 An in-depth description of GPs’ antibiotic prescribing patterns at baseline, using the same surveillance data but with slightly different eligibility criteria, has been presented elsewhere.5
In brief, this study was carried out in public and private general practices in Malta. A total of 370 GPs registered on the Malta Medical Council’s Specialist Register and 34 GP trainees were invited to the study. Seventy registered GPs and GP trainees responded, of which 35 agreed to participate. Prior to surveillance initiation, 2 GPs stopped working clinically; therefore, ultimately 30 GPs and 3 GP trainees participated.
Patient and public involvement
This study was conducted without patient or public involvement. Patients were not invited to comment on the study design and were not consulted to develop patient relevant outcomes or interpret results. Patients were neither requested to contribute to the writing or editing of this document for readability or accuracy.
During enrolment, GPs were asked to complete a background information sheet, which included information on demographics, training/experience and service delivery organisation (online supplementary figure S1). GPs registered patients seen for aRTCs during 12 predetermined surveillance weeks (1 week/month without substitutions) between May 2015 and April 2016. Forms were completed by the GPs themselves during the first consultation with patients of all ages suffering from any aRTC (defined as lower and upper respiratory tract infections, allergies and exacerbation of chronic obstructive pulmonary disease (COPD)/asthma/bronchitis), and included information on patient and clinical factors, clinical assessment, diagnosis and prescribed medicines. The surveillance data collection form has been published elsewhere.5 Data on the total number of patients seen each day, regardless of complaint, were also collected.
Communication was maintained with GPs throughout surveillance. Each surveillance week, GPs received 3 text messages, one to remind them to prepare for data collection, another to initiate it and a third to conclude it. GPs were also contacted by phone at most 4 times during the year, to provide encouragement and address queries. Moreover, GPs received 3 monthly individual-level and aggregate-level feedback reports on their prescribing patterns.
Only cases diagnosed with an aRTC were included in this study. Cases were only considered for analysis if they were consulting with the participating GP for the first time for that presenting complaint. Any follow-up visits recorded were automatically excluded. For the purpose of this analysis, all cases diagnosed with pneumonia were excluded from the dataset. Cases where more than one aetiology and/or diagnosis was provided or who were consulted over the phone, were also excluded from analysis. As a result, 313 aRTC cases were excluded from analysis following data cleaning, reducing our final sample size to 4518.
Data were analysed using Microsoft Excel 2010 and Stata/IC V.13.1. Surveillance items not marked were assumed not present and analysed as absent. Analyses were conducted using complete-case analysis. Descriptive statistics were calculated using frequencies and percentages, means and SDs, medians and IQRs as appropriate. The outcome of interest was antibiotic prescription (yes/no), defined as an oral antibiotic prescription issued for an aRTC during an in-person consultation, irrespective of the number of antibiotics given. It included both regular and delayed antibiotic prescriptions, the latter to be dispensed if symptoms persisted, typically after 48–72 hours. It did not include ‘delayed instruction’, that is, directions to follow-up for a prescription if symptoms persisted or worsened.
To control for clustering at the GP level, potential predictors of antibiotic prescription were assessed using population averaged models using generalised estimating equations. Frequency distributions of individual explanatory variables of interest were calculated and univariable associations between each variable and antibiotic prescription were subsequently assessed using unadjusted ORs and 95% CIs. Since we could not assume linearity to the outcome, all continuous variables were categorised. Individual signs and symptoms variables were only investigated if at least 5% of aRTC cases presented with that particular symptom. Multivariate Wald-type tests were performed on multilevel categorical variables to test the hypothesis of the overall association.
Potential predictors were included in the multivariable model if significant at p<0.2 at univariable level and excluded if there were issues with collinearity. A predictor was only kept in the multivariable model if it improved the model and its p value was less than 0.05. Ultimately, 4425 aRTC cases were included in the final multivariable model.
In this cohort of aRTC patients, 2034 (45.0%) received an antibiotic prescription, of which 333 (16.4%) were delayed.
Most GPs were male (n=24; 73%). Mean age (years) was 49±12 and mean years of GP practice was 23±11. Eleven (33%) GPs worked exclusively in the public sector while 20 (61%) worked in the private sector (including private pharmacy clinics). Two (6%) worked in both sectors. Online supplementary table S1 summarises the GP characteristics.
Just over half of patients were female (n=2395; 53.1%) and the median age was 29 years (IQR=12–48). Over a third had completed up to secondary school education (n=3050; 68.0%). Smoking was reported in 735 (16.5%) cases. A summary of the patients’ sociodemographic and lifestyle characteristics is presented in online supplementary file 1.
Factors associated with antibiotic prescribing
The univariable and multivariable associations between GP, practice and consultation-level factors (table 1), patient sociodemographic factors (table 2), clinical factors (table 3) and antibiotic prescription are described below.
Univariable analysis revealed numerous factors associated with antibiotic prescribing. At GP level, GP age was identified as an important predictor with GPs aged 60 and older being most likely to prescribe antibiotics. At consultation level, regular clients and patients who asked for antibiotics were more likely to receive an antibiotic prescription. Patient sociodemographic factors associated with antibiotic prescription included female sex, patient age (particularly those aged 65 and older) and being a smoker. Finally, a number of patient health status factors were significantly associated with antibiotic prescription at univariable level, with the most important being fever >38.5°C, tender cervical nodes and total number of signs and/or symptoms with the odds of prescription increasing as the number increased.
In the final multivariable model, female GPs were 2.3 times more likely to prescribe antibiotics (95% CI 1.22 to 4.26) and, compared with younger GPs aged between 28 and 39 years, GPs aged 5–59 (OR 2.1, 95% CI 1.19 to 3.77) or 60 years and older (OR 34.7, 95% CI 14.14 to 84.98) were more likely to prescribe antibiotics. Increasing patient age also increased the likelihood of receiving an antibiotic prescription, with patients aged 65 and older being the most likely to receive a prescription (OR 2.3, 95% CI 1.71 to 3.18). The more signs and/or symptoms a patient presented with, the more likely they were to be given an antibiotic, with patients having four or more signs and/or symptoms being the most likely (OR 9.6, 95% CI 5.78 to 15.99). Additionally, patients with fever >38.5°C (OR 2.6, 95% CI 2.08 to 3.26), productive cough (OR 1.3, 95% CI 1.03 to 1.61), otalgia (OR 1.3, 95% CI 1.01 to 1.76), tender cervical nodes (OR 2.2, 95% CI 1.57 to 3.05), regular clients (OR 1.3, 95% CI 1.05 to 1.66), patients who requested antibiotics (OR 4.8, 95% CI 2.52 to 8.99) and smokers (OR 1.4, 95% CI 1.13 to 1.71), were also more likely to be prescribed an antibiotic. Conversely, patients with non-productive cough (OR 0.3, 95% CI 0.26 to 0.41), sore throat (OR 0.6, 95% CI 0.53 to 0.78), rhinorrhoea (OR 0.3, 95% CI 0.23 to 0.36) or dyspnoea (OR 0.6, 95% CI 0.41 to 0.83) were less likely to be given an antibiotic prescription.
This is the first study in Malta that identifies factors associated with antibiotic prescribing for aRTCs in the community, using surveillance data. While univariable analysis revealed numerous factors associated with antibiotic treatment, multivariable analysis identified several independent predictors of antibiotic prescription at different levels—provider, patient, consultation and clinical.
Our results pertaining to GP factors both converge and diverge from prior research. It has been suggested that high consultation rates may result in higher antibiotic prescription and in fact a Norwegian study was able to confirm this association.20 In our study however, despite GPs experiencing rather high daily patient loads, this did not influence their antibiotic prescription.
Similar to Akkerman et al,21 more years of GP experience were associated with increased antibiotic treatment. In contrast, an Italian study concluded the opposite, although the antibiotic prescribing of both GPs and paediatricians in children was investigated.22 Although we did not investigate years of GP practice specifically due to collinearity issues, we found a positive association between GP age and antibiotic prescription, which reflects the GPs’ years of practice. In Malta, family medicine was recognised as a specialty in 2004, after which doctors were legally required to undergo specialist training in family medicine. Through the ‘grandfather clause’, doctors who started training in Malta before November 2003 were eligible to acquire specialisation under certain criteria, essentially exempting them from specialist training.23 Lower antibiotic prescribing among younger GPs could be explained by the fact that they have more recently undergone specialist training. Older GPs may engage in more habitual behaviour and be in greater need of refresher courses and information on the latest antibiotic prescription guidelines.
Although it is well established that male and female physicians engage in different interaction and communication styles with patients,24 few studies have investigated the association between GP sex and antibiotic prescribing. Two recent studies investigating antibiotic prescription for aRTCs specifically, found that female GPs prescribe fewer antibiotics25 particularly to female patients,26 although the results were not statistically significant. Conversely, our findings revealed that female GPs in Malta are more likely to prescribe antibiotics. Although our sample is representative of the population for sex, we believe that further research is needed to explore and better explain this association.
In our study, antibiotic treatment increased significantly with age, with the elderly (≥65 years) most likely to receive a prescription. The age range of patients included in similar studies varies widely, with most only looking at patient subsets, making it difficult to compare findings on age. While we share similar results as studies carried out in Holland and Australia,27 28 in England/Wales and Sweden, high rates of antibiotic treatment were found among the elderly and children alike.29 30 In contrast, in Norway, it was found that patients aged 80 and over actually had the lowest odds of receiving an antibiotic prescription, followed by children younger than 6 years.20 Given that young children are more likely to visit their paediatrician in Malta, it is possible that more severe cases were missed in this study and that the youngest age groups are under-represented. The higher prescription rates among the elderly in Malta could suggest an augmented concern for their vulnerability towards severe infections, and an understanding that aRTCs in children are likely viral in origin.
Similar to other studies,31–33 being a current smoker was identified as an independent predictor of antibiotic prescribing. Doctors may feel that smokers will deteriorate without antibiotics, however, there is no evidence that antibiotics provide smokers greater clinical benefit or faster recovery.32 Fever, productive cough, otalgia or tender cervical nodes were also found to be independent predictors of antibiotic prescribing. Conversely, presenting with a sore throat, non-productive cough, rhinorrhoea or dyspnoea led to a decreased likelihood of prescription. Fever is frequently reported as a significant predictor of antibiotic prescription.33–35 An Italian study investigating antibiotic prescription in young children, similarly found that otalgia, cervical adenopathy or absence of rhinorrhoea among others were associated with antibiotic prescription.35 GPs could believe that certain clinical findings, that are often positively associated to prescription, indicate a bacterial infection or are a precursor for more serious illness.
Differentiating between bacterial and viral aetiologies based on signs and/or symptoms alone is challenging and a likely driver of antibiotic overprescription. Although some symptoms suggest a possible bacterial infection and could warrant further investigation, most uncomplicated viral respiratory tract infections last between 5 and 7 days and peak in severity at days 3–6.36 Given that most patients in this study presented within 3 symptomatic days, some may have benefited from a wait and see approach or delayed prescription, without negative consequences. In fact, a study which examined antibiotic prescribing for acute cough and its impact on recovery across 13 European countries found similar recovery rates in patients prescribed and not prescribed antibiotics.37 The potential role individual symptoms play in inappropriate antibiotic use should not be overlooked, as it has been indicated that Maltese respondents take antibiotics primarily to treat symptoms as opposed to illnesses.16
Being a regular client also contributed to increased likelihood of antibiotic prescribing in this study. Given the structure of primary healthcare in Malta, private sector GPs, who simultaneously compete for business and whose patients pay out-of-pocket, may be eager to please. In fact, research suggests that a trade-off may exist between prudent antibiotic use and cultivating a positive doctor–patient relationship.38 This is also impacted by expectations and studies have shown that both doctors’ belief that a patient expects antibiotics, and patients’ actual expectations for antibiotics are associated with antibiotic prescription.39–41 Requesting antibiotics was an important predictor of antibiotic prescription in our study. While some studies have shown that providing an antibiotic prescription to such patients increased patient satisfaction,38 39 others suggest that it does not, indicating instead that receiving information when an antibiotic is expected but not needed is as important as receiving a prescription.42 While it is imperative to understand why patients expect antibiotics and what determines patient satisfaction in Malta, GPs need to find alternative strategies to ensure patient satisfaction without providing an unwarranted antibiotic prescription. One strategy is enhancing doctor–patient communication through communication skills training. Effective communication together with information tools could facilitate decision-making and empower doctors to decline antibiotic requests when unnecessary.43 This is important, as receiving an antibiotic, particularly when expected, reinforces patients’ desire for prescriptions and their perception that they should consult a GP for a similar problem in the future.44
A study carried out in Spain also showed that having access to point-of-care tests (rapid antigen detection tests and C reactive protein) was associated with an 18.9% lower antibiotic prescription rate among antibiotic-requesting patients.45 Having access to rapid tests could help GPs to support their decision not to prescribe by reducing uncertainty thereby lessening the risk that they give in to patient demand, while providing reassurance to patients.45 46 In Malta, point-of-care tests are largely unavailable, which may augment diagnostic uncertainty. Coupled with patient demand for antibiotics, this exerts prescribing pressure on GPs and may result in an unnecessary prescription. Malta possesses a culture that scores high for uncertainty avoidance, a cultural dimension that has consistently been reported as a potent driver for unnecessary antibiotic use.14 15 47 Efforts should be made to make low-cost, rapid diagnostics more readily available since these could reduce diagnostic uncertainty and lessen the pressure to prescribe an empiric antibiotic. However, their introduction must be approached with caution to avoid introducing new elements of uncertainty, addressing system factors such as the out-of-pocket cost of tests on the overall consultation, combined with training and support to encourage acceptance. Likewise, patients should be informed about the possibility of low-cost testing to avoid unnecessary antibiotic consumption, thereby safeguarding themselves and their future.
Strengths and limitations
Knowledge on the drivers of antibiotic prescribing in southern European countries with high antibiotic consumption rates is largely lacking, limiting our ability to develop targeted interventions. A first of its kind in Malta, this study paves the way for more research on antibiotic prescribing for aRTCs and other indications in the outpatient sector. The sample of 4518 aRTC cases was sufficient to analyse a large number of potential explanatory variables in multivariable analysis. Data collection tools were adapted from materials used in previous research48 49 and piloted in the Maltese context. Through user-friendly surveillance forms, we acquired data on provider, patient, consultation and clinical factors which could impact antibiotic prescribing, allowing for deeper analysis of potential influencing factors compared with studies that only examine a subset of these characteristics. The simple to complete forms were intended to aid documentation of as many aRTC cases as possible, while reducing GP drop-outs and non-reporting. Given its design and incorporation into clinical practice, it may have helped reduce the effect of observation bias.10
Still, this study does have limitations. Since GPs participated voluntarily, it is possible that participants were more interested in the research area or more conservative prescribers than non-participating GPs. Therefore, our GP sample may not be representative of all Maltese GPs. The audit-based nature of the study may have resulted in measurement error; it is possible that GPs completed patient background information that was atypical to ask during a normal consultation without directly asking the patient. It is also possible that variables of interest located at the end of the surveillance sheet were left unmarked and inaccurately assumed to be non-cases. Lastly, GPs were issued 3 monthly feedback reports and since audit and feedback is a behavioural change intervention in itself it is possible that the antibiotic prescribing rate was affected as a result. However, prior research on the association between surveillance participation and GPs’ antibiotic prescription patterns has produced mixed results; a recent randomised control trial reported no effect.50
CONCLUSION AND IMPLICATIONS FOR RESEARCH AND POLICY
Our study sheds light on key drivers of community-level antibiotic prescribing for aRTCs in Malta, providing missing scientific evidence necessary to develop tailored interventions aimed at improving prudent antibiotic use. Furthermore, we believe that our study could help guide antimicrobial stewardship initiatives in the community in countries with similar sociocultural traits.
Addressing inappropriate antibiotic prescribing in primary care requires multifaceted interventions that focus on educating providers and patients alike, while providing them with the tools required to ensure that antibiotics are prescribed appropriately and taken only when necessary. Although more experienced GPs could benefit from targeted antibiotic stewardship activities, ongoing continuing medical education initiatives for all GPs are important to ensure that appropriate antibiotic prescription practices are maintained. Communication training in particular is needed to facilitate decision-making and empower doctors to decline antibiotic requests. National antibiotic guidelines should include other diagnostic criteria such as smoking status and better promote the use of delayed antibiotic prescription, particularly in high-prescription contexts. Finally, in settings with high uncertainty avoidance, improving access to low-cost, rapid tests could prove beneficial in supporting GPs’ prescribing decisions.
We would like to extend our gratitude to all participating GPs for their dedication throughout this study. Thanks also to Senia Rosales-Klintz for her support and for helping setting up this surveillance study. We also thank Wilfred Galea (TheSynapse, https://thesynapse.net) and Philip Sciortino (Malta College of Family Doctors) for assisting us during GP recruitment. Finally, thank you Cecilia Lindsjö and Vijaylakshmi Prabhu for helping with data input and feedback report writing, and Raycine Debono for assistance with data management.
Contributors EASG, CSL and MAB were involved in the conception of the research study and design of the surveillance data collection sheet. EASG carried out all data collection and was responsible for data management throughout the study’s duration. This included maintaining contact with all GPs and overseeing the writing of feedback reports which were subsequently distributed by EASG. EASG and ADH cleaned the dataset. EASG ran statistical analyses with input from ADH and NO. EASG was responsible for drafting the manuscript. EASG, ADH, PZ, NO, MAB and CSL were involved in the interpretation of data and critical revision of the manuscript. EASG produced the final version of the manuscript which was approved by all authors.
Funding This work was supported by Karolinska Institutet funding for doctoral education (KID-funding 3–1233/2013). It was also supported by funding available to CSL at Karolinska Institutet. This research received no other specific grant from any public, commercial or not-for-profit funding agencies.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval The University of Malta Research Ethics Committee granted ethical approval and research was conducted in accordance with the Declaration of Helsinki. GP participation was voluntary and informed consent was obtained. GPs could terminate participation at any time, for any reason, without consequence. GP identities were masked using randomly assigned unique identification codes and no personal information was made public. Finally, all patient data collected by GPs was non-identifiable.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement All data relevant to the study are included in the article or uploaded as online supplementary information.
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