Objectives Although depressed patients may have a comorbid eating disorder (ED), to date, no study has focused on healthcare utilisation among this population. This study was designed to investigate the characteristics of healthcare service utilisation among depressed patients with ED.
Design A cross-sectional study.
Setting This population-based study used claims data from Taiwan’s National Health Insurance Research database between 2001 and 2012.
Participants The study involved 1270 participants. These included 254 depressed individuals with ED and 1016 propensity score-matched depressed individuals without ED.
Outcome measures We tracked each patient for a 1 year period to evaluate their healthcare service utilisation, including outpatient visits, inpatient days, and costs for psychiatry and non-psychiatry services. We performed a Mann-Whitney U test to compare outcome variables in healthcare service utilisation between the two groups.
Results Patients with both depression and ED had significantly more outpatient visits (32.2 vs 28.9, p=0.023), outpatient costs (US$1089 vs US$877, p<0.001) and total costs (US$1356 vs US$1296, p<0.001) than comparison patients. For psychiatric services, patients with depression and ED had more outpatient visits (11.0 vs 6.8, p<0.001), outpatient costs (US$584 vs US$320, p<0.001) and total costs (US$657 vs US$568, p<0.001) than those without ED. For non-psychiatric services, there was no significant difference for all utilisation. This indicates that the total costs were about 1.0-fold greater for depression patient with ED than those without ED.
Conclusion Depression patients with ED had more outpatient visits, outpatient costs and total costs of healthcare services than those without ED.
- eating disorder
- health services utilization
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Statistics from Altmetric.com
Strengths and limitations of this study
This is the first Asian study to investigate the characteristics of the healthcare utilisation and costs of depressed patients with eating disorder.
This study was a cross-sectional study using a large population-based dataset with extensive health welfare coverage from Taiwan.
The advantage of this study was the use of data from a single-payer system national health insurance programme.
This study did not estimate indirect costs or intangible costs, such as societal costs (eg, productivity losses and informal caregiving).
As the dataset used in this study lacked figures for out-of-pocket fees, this study might underestimate hospital treatment costs.
Eating disorders (EDs) are psychiatric disorders characterised by both physical and psychological disturbances. The core symptoms of eating disorder (ED) include abnormal eating patterns and weight control behaviour. These illnesses affect not only psychological, social, occupational, and quality of life factors, but also increase mortality rates.1 2 EDs include anorexia nervosa (AN), bulimia nervosa (BN) and eating disorder not otherwise specified (EDNOS). The majority of ED occur among women, and they have high rates of comorbidity with mental illness, especially depressive disorders.3–8 Specifically, depression is one of the most common mental illnesses in the world and is expected to become the second-largest cause of global disease burden worldwide by 2020.9 Studies have also reported on its economic burden.10–12 The cost of depression is high, and it is associated with suicidal risk.13 Previous studies suggest that the use of healthcare services by depressed patients exceeds that of similar non-depressed patients by 50%–100%.14 In Taiwan, the cost of depression increased continuously between 2000 and 2002,15 and the use of three kinds of psychotropic drugs also increased greatly from 1977 to 2004.16 Nevertheless, depression is the most common comorbid diagnosis among patients with ED17 18 and the development of the two overlaps. The lifetime comorbidity of depression has been reported as 40% among patients with AN and 50% among patients with BN.19 Comorbid depressive symptoms have been found to have negative impacts on patients with ED.20 Despite the above-mentioned findings, the relationship between ED and depression is still unclear.
Many studies have indicated that depression occurs before ED diagnosis.21–24 Our previous work also found that the risk of suicide was 1.8 times higher among patients with ED with pre-existing comorbid depression.5 However, few studies have investigated healthcare utilisation preceding ED diagnosis.25–27 One study reported that the healthcare costs of ED are similar to those of depression.25 However, there is little knowledge about the use and cost of services after diagnosis.28 29 Another review article stated that early (1982–2002) studies of health service use and costs for ED employed limited evidence and underestimated the costs; the review speculated that the economic burden is likely to be substantial.30
According to our review of the relevant literature, no study thus far has focused on the healthcare utilisation of depressed patients with ED in Western or Asian countries. Our previous work showed that patients with both depression and ED warrant special care as they might respond poorly to the usual treatments and be at a higher risk of suicidality. Thus, the aim of the present study was to investigate healthcare utilisation and expenditures among depressed patients with and without ED in Taiwan. We further compared psychiatric and non-psychiatric healthcare utilisation between depressed patients with and without ED. We hypothesise that there have been increases in healthcare utilisation in depression patients accompanied by ED, even after other comorbidities have been matched.
This study used the Longitudinal Health Insurance Database 2005 (LHID 2005), derived from Taiwan’s National Health Insurance Research Database (NHIRD), which contains the data of over 99% of the people (around 23 million residents) in Taiwan. This is a single-payer National Health Insurance Program begun on 1 March 1995. The LHID 2005 contains all original claims data from 25.68 million beneficiaries randomly sampled in the year 2005 from the NHIRD. There was no significant difference in the gender or age distributions of the patients in the LHID 2005 and the original NHIRD. Disease diagnosis was performed using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnostic codes.
Study participants and design
In total, 39 214 patients included in the study had a major depressive disorder and neurotic depression (ICD‐9‐CM codes 296.20 to 296.26, 296.30 to 296.36, 296.82 and 300.4) between 2001 and 2012. The patients with three or more outpatient visits or at least one hospitalisation were identified as depression cases. We excluded 475 subjects who died within 1 year, 721 children aged <10 years and 653 subjects with histories of special diseases (ICD‐9‐CM codes 759.81, 536.2, 346.2 and 306.4). After that, 37 365 patients remained, who were divided into participant groups with or without ED diagnoses (ICD‐9‐CM codes 307.1, 307.5, 307.51–4 and 307.59). ED was defined as an ED diagnosis made after depression diagnosis and three or more outpatient visits or at least one hospitalisation. Then, in order to eliminate potential effects due to baseline comorbidities between the two groups, we used 1:4 propensity score-matched controls from among the patients with depression who were randomly matched with the cases. Propensity score matching (Mahalanobis Metric Matching) was used to balance underlying demographics including sex, age, comorbidities and year of the depression index date, which might be unequally distributed between cases and controls at baseline (figure 1).
In this study, all sampled patients were tracked for a 1-year study period starting at the index date to evaluate their healthcare service utilisation and expenditures. The healthcare expenditure included ambulatory care costs by visit and inpatient costs by admission per person per year. As the NHIRD includes payment amounts, we treat the value of the costs as presented in US dollars at a fixed rate of 30 New Taiwan dollars (NT$) to US$1.0. Variables of healthcare resource utilisation in this study were defined as follows: (1) mean numbers of outpatient visits, (2) mean costs of outpatient services, (3) mean numbers of inpatient days and (4) mean costs of inpatient services during the 1 year follow-up period. Additionally, we divided healthcare resource utilisations into psychiatric services and non-psychiatric services.
We defined baseline comorbidities, including major physical and mental disease, as potential confounders in this study because they are potentially associated factors for depression and ED. These included diabetes (ICD-9-CM code 250), hypertension (ICD-9-CM codes 401–405), hyperlipidaemia (ICD-9-CM code 272), cardiovascular disease (ICD-9-CM codes 390–398, 410–414 and 420–429), cerebral vascular accident (ICD-9-CM codes 430–438), anxiety disorder (ICD-9-CM code 300 except 300.4), bipolar disorder (ICD-9-CM codes 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.80, 296.81, 296.89 and 296.90), schizophrenia (ICD-9-CM code 295), substance use disorder (ICD-9-CM codes 291, 292, 303, 304 and 305) and personality disorder (ICD-9-CM code 301).
A χ2 test and an independent t-test were used to compare the demographic characteristics among the groups. Means and SD and frequency (%) were used to report the baseline demographic and clinical characteristics of the study population. Due to the distributions of outcome variables (mean outpatient visits, costs, inpatient days and so on) being skewed, we thus used the non-parametric Mann-Whitney U test to analyse the differences in variables of healthcare service utilisation between the two group. All analyses were carried out with SAS V.9.4. A two-sided p-value of ≤0.05 was considered statistically significant.
Patient and public involvement
Patients or public were not involved in the research, including development of the research question, outcome measures, study design, recruitment and conduct of the study.
The population-based study involved a total of 1270 participants. These included 254 depressed individuals with ED (depression+ED group) and 1016 depressed individuals without ED (depression group). The mean participant age was 29.3 years. About 94% of the patients were women, and 52.7% of the patients lived in urbanised areas. More than half (54%) had comorbid anxiety. Overall, the matched procedure was not significant between groups with regard to the distributions of age, sex, urbanisation level, income and comorbidities. The demographic characteristics are shown in table 1.
Healthcare utilisation and costs
Table 2 shows healthcare service utilisation in the 1-year period following the index date of depressed patients with and without ED. The depression+ED group had significantly more outpatient visits (32.2 vs 28.9, p=0.023), outpatient costs (US$1089 vs US$877, p<0.001) and total costs (US$1356 vs US$1296, p<0.001) than the depression group. However, healthcare utilisation did not significantly differ in terms of inpatient days (1.6 vs 4.4, p=0.301) and costs (US$267 vs US$418, p=0.214) between the two groups. This indicates that total costs were about one-fold greater for depression patients with ED than those without ED.
We categorised patients into two levels of depression severity according to the median number of depression outpatient visits (median depression outpatient visits=11), as shown in the online supplementary table 1. Severe depression with patients with ED had significantly higher outpatient costs (US$1291 vs US$1153, p=0.021) and total costs (US$1552 vs US$1,488, p=0.018) than patients with only severe depression. Similarly, we categorised depression patients according to the severity of ED, as shown in the online supplementary table 2. The results indicate that patients with severe ED had significantly more outpatient visits, greater outpatient costs and total costs than mild or no ED with depression patients. We considered all costs to be adjusted for inflation, as shown in the online supplementary table 3. In addition, we used the bootstrapping method to compare the mean cost differences between the two groups, as shown in the online supplementary table 4.
Psychiatric and non-psychiatric service utilisation
We further analysed the service utilisation of medical resources in psychiatry and non-psychiatry departments, as shown in table 3. Regarding psychiatric medical resource utilisation analysis, we found that the depression+ED group had significantly more outpatient visits (11.0 vs 6.8, p<0.001), outpatient care costs (US$584 vs US$320, p<0.001) and overall total costs (US$657 vs US$568, p<0.001) than the depression group. However, the depression+ED group had fewer hospital stays (0.8 vs 3.4, p=0.711) and lower hospitalisation costs (US$73 vs US$249, p=0.565) than the depression group, though the difference was not significant. We also found that psychiatric total costs were about 1.2 times greater for depression patients with ED than those without ED.
In the non-psychiatric medical resource utilisation analysis, we found that there were no significant differences in outpatient or hospitalisation visits, outpatient or hospitalisation care costs, or overall total costs between the two groups. However, the depression+ED group visited non-psychiatric clinics more often than psychiatric clinics (21.3 vs 11.0), even though the expense of a non-psychiatric outpatient clinic was lower than a psychiatric clinic (US$505 vs US$584). On the other hand, the cost of hospitalisation in a non-psychiatric ward (US$194 vs US$73) was higher than that of psychiatric admission among the depression+ED group, though there was no difference in the days of admission between non-psychiatric and psychiatric hospitalisation (0.7 vs 0.8). Additionally, we found that both groups had more total costs for non-psychiatric care than psychiatric care (depression+ED group: US$699 vs US$657; depression group: US$727 vs US$568). Therefore, this highlights that the utilisation of outpatient services is noteworthy.
In both groups, further analysis found that the subjects most often visited the psychiatric department (34% vs 23.6%), followed by internal medicine (9.4% vs 11.6%), obstetrics and gynaecology (8.6% vs 9.2%), traditional Chinese medicine (TCM) (8.1% vs 10.4%), family medicine (7.5% vs 8.1%), dentistry (7% vs 5.9%) and otolaryngology (4.9% vs 6.7%), as shown in figure 2.
This study is one of the first to analyse the healthcare utilisation of depressed patients with and without ED using a health insurance database. We report several notable findings. First, the depressed patients with ED utilised healthcare more in terms of outpatient visits, outpatient costs and 1.0-fold higher total costs than patients without ED, though their inpatient days and costs were lower. These findings corroborate previous reports that patients with both ED and depression used more outpatient than inpatient treatment, regardless of gender or type of ED.28 It has also been found that these results are similar to previous findings on healthcare utilisation of patients with ED.25 27 28 For instance, one study examined a large healthcare organisation in the USA and demonstrated that psychiatric comorbidity and healthcare service use were significantly elevated among women both before and after ED diagnosis.27 It was found that female patients with anorexia nervosa had more outpatient visits and outpatient expenditures than the controls.31 Additionally, the emotional symptoms associated with depressive disorders might lead to increased use of general medical services or emergency departments.32 On the other hand, somatic symptoms such as pain, fatigue, disturbed sleep, gastrointestinal disturbances and unexplained somatic symptoms have been reported as leading causes of outpatient visits for patients with depression.33 34 Considering the development of the combination of ED and depressive symptoms, a number of theoretical models have suggested frameworks that propose shared and specific risk factors, including biological/genetic,35 cognitive,36 emotional regulation37 and feminist models.38 Therefore, it is not surprising that depressed patients with ED had greater healthcare utilisation of outpatient services than those without ED. Another possible explanation is that most patients in our study were urban residents, which improves the convenience of general medical treatment. In our study found that those patients are associated with markedly higher healthcare utilisation, even after controlling for other psychiatric and physical comorbidities.
Second, the present study findings indicated that depressed patients with ED used psychiatric outpatient services more often than those without ED. Notably, they also made more non-psychiatric outpatient visits than psychiatric visits. Earlier studies indicated that during the 5 years preceding ED diagnosis, these patients consulted general medical doctors significantly more frequently than those without ED.26 Previous literature showed that patients with ED visited general medical doctors for emotional problems and/or for weight loss, and fewer patients sought treatment specifically for ED by a psychiatrist.19 39 Van Son et al indicated that patients with BN tended to seek general medical help for somatic problems rather than for mental health issues, whereas patients with AN are thought to be prone to somatic complications due to malnourishment.40 We speculate that these patients might feel ashamed to seek help for eating problems41 or that physicians fail to assess for42 or recognise ED symptoms.43 Another possibility is that they did not feel that the somatic problems were related to the ED by themselves. The present study confirmed that patients with ED often seek help from medical departments other than psychiatry. This perhaps reflects that early ED symptoms are not easily detected and are undertreated, leading to underestimating the incidence of ED.
Third, the results suggest that patients with depression and ED prefer to seek treatment across different departments. Our analysis further showed that in addition to seeking psychiatric help, they also frequently visited internal medicine, gynaecology, TCM and family medicine departments. Early studies found that most individuals with depression typically presented with psychological, gastrointestinal or gynaecological complaints, which might be prompted by symptoms of an ED.26 44 Patients with ED frequently have gastric emptying abnormalities, which cause bloating, postprandial fullness and vomiting.45 The gynaecological complaints were mostly of amenorrhoea or irregular periods.46 Therefore, we believed that these features might be potential risk factors for increased healthcare utilisation among depressed patients with ED. It is suggested that clinicians pay attention to possible signs and symptoms of ED in patients with depression. Additionally, it is worth mentioning that TCM has been used to treat depression-like symptoms.47–49 In Taiwan, younger people with depression were more likely to use TCM than older populations.48 Some studies have shown that depressed patients may use TCM mainly for treating sleep problems,50 respiratory conditions51 or painful physical symptoms.52 Therefore, the utilisation of TCM services could have a substantial impact on the healthcare costs of patients with depression.
An advantage of the present study is the use of data from a single-payer national health insurance programme, as well as a population-based dataset with extensive health welfare coverage. The database includes the complete utilisation of information and medical costs for almost all people in Taiwan. Thus, this study completely avoids the potential risk of recall bias. Nevertheless, there are several limitations to this study. First, we did not classify the subtypes of depression or an ED, duration of illness, date of onset of depression, family history of depression or comorbidity of depression, such as alcohol or substance use. The lack of a classification of the subtypes of depression or ED may limit the generalisation of our findings. In addition, the comorbidity of physical or psychiatric disorders might confound the relationship between disease and health utilisation. Second, there were no laboratory data included in this analysis. Thus, there may be missing information on the physical conditions related to ED, such as electrolyte imbalance, endocrine abnormality, and liver or renal abnormality, which may complicate the treatment course of patients and interfere with our analysis of health utilisation. Third, we did not include the evaluation of impaired functions, which may be associated with indirect costs of illness. Other than health utilisation, the indirect costs may reflect the functionally impaired rather than the severity of the physical or psychiatric symptoms of the disease itself. It usually remained subtle, but significantly reduced the welfare of not only the patients but even their family and coworkers. Fourth, because the dataset lacked records of out-of-pocket expenses, this study might underestimate hospital treatment costs. Finally, we could not further analyse the healthcare utilisation of ED subtypes. Future research is warranted to investigate the impact of societal burdens among these patients, especially in terms of their lost productivity due to the inability to work or premature death.
Depressed patients with ED showed higher healthcare utilisation than those without ED, especially outpatient visits, outpatient costs and total costs. Additionally, these patients often visited psychiatric clinics, followed by internal medicine, gynaecology, TCM and family medicine. Clinicians should pay attention to possible signs and symptoms of ED in patients with depression, and early appropriate treatment for ED should be considered. Nevertheless, a future study may further explore the factors potentially leading to increased healthcare expenditures by depressed patients with ED.
Thanks for grants MOST105-2314-B-016-016-MY3, TSGH-C108-160, TSGH-C108-149. The authors thank all the research associates for their contributions to this work and feedback. The database used in this study derives from Taiwan’s National Health Insurance Research Database (NHIRD). Our explanations and conclusions do not represent the views of the National Health Insurance Research Database (NHIRD) in Taiwan.
Contributors CLY: study methodology, literature review, data analysis, and manuscript writing. LTK: data collection, statistical analysis, and interpretation of the results. MKY: manuscript revision and administrative support. WCC: study methodology and administrative support. CBY: planning of the study, analysis and interpretation of the data, and critical revision of the manuscript for important intellectual content. All authors reviewed and approved the final manuscript for submission.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval This study was exempt from full review by the Tri-Service General Hospital Institutional Review Board (TSGHIRB No. 1-104-05-048). Our study was conducted in accordance with the Helsinki Declaration. The informed consent of patients was not required for this study, as they were not asked to follow rules of behavior. All personal patient data were coded and patient anonymity was guaranteed.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement No data are available.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.