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Sexually transmitted infections among high-risk populations that use treatment as prevention or pre-exposure prophylaxis: a protocol for a systematic review
  1. Makella Coudray1,
  2. Sandra Kiplagat1,
  3. Franklin Saumell1,
  4. Purnima Madhivanan2,3,4,5
  1. 1 Epidemiology, Florida International University, Miami, Florida, USA
  2. 2 Health Promotion Sciences, Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States
  3. 3 Internal Medicine, Division of Infectious Diseases, College of Medicine, University of Arizona, Tucson, Arizona, United States
  4. 4 Family & Community Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States
  5. 5 Public Health Research Institute of India, Mysore, Karnataka, India
  1. Correspondence to Miss Makella Coudray; mcoud001{at}fiu.edu

Abstract

Background Among men who have sex with men, pre-exposure prophylaxis (PrEP) reduces the risk of HIV by 95%. Based on the documented benefits, the Centre for Disease Control and Prevention has recommended PrEP as a prevention method for high-risk groups. Moreover, for those HIV-infected individuals, antiretroviral therapy has been shown to serve as both as a treatment and prevention method for HIV.

Methods and analysis This systematic review protocol was reported according to the Preferred Reporting Items for Systematic reviews and Analyses (PRISMA) P framework. Medline (1980–present), Embase (1980–present), CINAHL (1980–present), Cochrane Central Register of Controlled Trials and clinicaltrials.gov will be used to identify relevant articles based on a piloted search strategy. Peer-reviewed observational and experimental studies will be included. A narrative style will be used to describe descriptive data. A meta-analysis will be conducted if heterogeneity is not significant.

Ethics and dissemination Recent evidence suggests that there is an increased risk of sexually transmitted infections (STIs) among high-risk persons that use PrEP. Furthermore, there is a paucity of data on the relationship of treatment as prevention and incidence of STIs. The findings of this review will assess this emerging public health phenomenon and serve to inform future public health policy. No formal ethical review is required for this protocol. All findings will be published in a peer reviewed journal.

PROTOCOL registration number CRD42019128720.

  • HIV & AIDS
  • treatment
  • PrEP
  • TasP

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Footnotes

  • MC and SK are joint first authors.

  • MC and SK contributed equally.

  • Contributors MC and SK: study concept and design, drafting of manuscript. FS: drafting of manuscript. PM: subject matter expertise, revision of manuscript, obtained funding

  • Funding MC and PM are supported by the National Institutes of Health grant (R15AI28714-01).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement There are no data in this work.

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