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  • Characteristics and utilisation of the Mayo Clinic Biobank, a clinic-based prospective collection in the USA: cohort profile

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Epidemiology
Cohort profile
Characteristics and utilisation of the Mayo Clinic Biobank, a clinic-based prospective collection in the USA: cohort profile
  1. Janet E Olson1,
  2. Euijung Ryu2,
  3. Matthew A Hathcock2,
  4. Ruchi Gupta2,
  5. Joshua T Bublitz2,
  6. Paul Y Takahashi3,
  7. Suzette J Bielinski1,
  8. Jennifer L St Sauver1,
  9. Karen Meagher4,
  10. Richard R Sharp4,
  11. Stephen N Thibodeau5,
  12. Mine Cicek5,
  13. James R Cerhan1
  1. 1Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
  2. 2Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
  3. 3Division of Primary Care Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
  4. 4Biomedical Ethics Research Program, Mayo Clinic, Rochester, Minnesota, USA
  5. 5Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Janet E Olson; olsonj{at}mayo.edu

Abstract

Purpose The Mayo Clinic Biobank was established to provide a large group of patients from which comparison groups (ie, controls) could be selected for case–control studies, to create a prospective cohort with sufficient power for common outcomes and to support electronic health record (EHR) studies.

Participants A total of 56 862 participants enrolled (21% response rate) into the Mayo Clinic Biobank from Rochester, Minnesota (77%, n=43 836), Jacksonville, Florida (18%, n=10 368) and La Crosse, Wisconsin (5%, n=2658). Participants were all Mayo Clinic patients, 18 years of age or older and US residents.

Findings to date Overall, 43% of participants were 65 years of age or older and female participants were more frequent (59%) than males at all sites. Most participants resided in the Upper Midwest regions of the USA (Minnesota, Iowa, Illinois or Wisconsin), Florida or Georgia. Self-reported race among Biobank participants was 90% white. Here we provide examples of the types of studies that have successfully utilised the resource, including (1) investigations of the population itself, (2) provision of controls for case–control studies, (3) genotype-driven research, (4) EHR-based research and (5) prospective recruitment to other studies. Over 270 projects have been approved to date to access Biobank data and/or samples; over 200 000 sample aliquots have been approved for distribution.

Future plans The data and samples in the Mayo Clinic Biobank can be used for various types of epidemiological and clinical studies, especially in the setting of case–control studies for which the Biobank samples serve as control samples. We are planning cohort studies with additional follow-up and acquisition of genetic information on a large scale.

  • cohort
  • mayo clinic biobank
  • electronic health records

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2019-032707

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    Footnotes

    • Collaborators All data from the Mayo Clinic Biobank presented in this article are stored by the research group of the authors on safe servers at Mayo Clinic, USA and handled confidentially. To apply for access to data, contact Biobank@mayo.edu and request the current application for access to samples and/or data. Due to the specifics of the informed consent language, a Mayo Clinic researcher must be included as a collaborator on all projects. If you cannot identify a staff member of Mayo Clinic, one can be identified for you. Contact Dr Janet E Olson (olsonj@mayo.edu) for enquires. More information is available at our website at: https://www.mayo.edu/research/centers-programs/mayo-clinic-biobank/overview.

    • Contributors JEO, ER, PYT, SNT and JRC jointly conceived the study. ER, MAH, RG and JTB handled the data management and analyses. JEO and ER drafted the manuscript. SJB, JSS, KM, RRS, MC and JRC critically revised the manuscript for important intellectual content. JEO and ER were responsible for the final version of the manuscript.

    • Funding The creation and operation of the Mayo Clinic Biobank is supported by funding provided by the Mayo Clinic Center for Individualized Medicine.

    • Map disclaimer The depiction of boundaries on the map(s) in this article do not imply the expression of any opinion whatsoever on the part of BMJ (or any member of its group) concerning the legal status of any country, territory, jurisdiction or area or of its authorities. The map(s) are provided without any warranty of any kind, either express or implied.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.