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Quality of life and objective functional impairment in lumbar spinal stenosis: a protocol for a systematic review and meta-analysis of moderators
  1. Fabio Ferretti1,
  2. Anna Coluccia1,
  3. Roberto Gusinu2,
  4. Giacomo Gualtieri3,
  5. Vitaliano Francesco Muzii1,
  6. Andrea Pozza1
  1. 1Department of Medical Sciences, Surgery and Neurosciences, Santa Maria alle Scotte University Hospital of Siena, Siena, Italy
  2. 2Health Service Management Board, Santa Maria alle Scotte University Hospital, Siena, Italy
  3. 3Legal Medicine Unit, Santa Maria alle Scotte University Hospital, Siena, Italy
  1. Correspondence to Dr Andrea Pozza; andreapozza7{at}gmail.com

Abstract

Background Lumbar spinal stenosis (LSS) is a common degenerative spine disease associated with a strong impairment in various quality of life areas, particularly the ability to perform work-related activity. Depression is a condition frequently associated. There is no comprehensive review on quality of life and objective functional impairment in LSS. This paper presents the protocol of the first systematic review and meta-analysis summarising evidence about quality of life and functional impairment in patients with LSS compared with healthy controls. Comorbid depressive disorders, age, gender, LSS duration, disability, pain severity and study methodological quality will be investigated as moderators.

Methods The protocol is reported according to PRISMA-P guidelines. Studies will be included if they were conducted on patients aged 18 years old or older with primary LSS and if they reported data on differences in the levels of quality of life or objective functional impairment between patients with LSS and healthy controls. Independent reviewers will search published/unpublished studies through electronic databases and additional sources, will extract the data and assess the methodological quality. Random-effects meta-analysis will be carried out by calculating effect sizes as Cohen’s d indices. Heterogeneity will be examined by the I2 and the Q statistics. Moderators will be investigated through meta-regression.

Conclusions A summary of the evidence on quality of life and functional impairment in LSS may suggest clinical and occupational health medicine strategies aimed to timely detect and prevent these outcomes. Higher percentages of patients with LSS with depression may be expected to be related to poorer quality of life. Depressive comorbidity might impact negatively on quality of life because it is associated with dysfunctional coping, disability and psychophysiological symptoms.

Ethics and dissemination The current review does not require ethics approval. The results will be disseminated through publications in peer-reviewed journals.

Review registration CRD42019132209.

  • lumbar spinal stenosis
  • health-related quality of life
  • disability
  • well-being
  • systematic review
  • depression

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Footnotes

  • Contributors FF conceived and designed the study, wrote the first draft of the paper and reviewed the final draft. AC conceived and designed the study, critically reviewed the first draft of the paper and reviewed the final draft. RG critically reviewed the last draft of the paper. GG critically reviewed the last draft of the paper. VFM conceived and designed the study, and critically reviewed the first draft of the paper. AP conceived and designed the study, wrote the first draft of the paper and reviewed the final draft. All the authors approved the final version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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