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Polymorphisms of genes related to vitamin D metabolism and transportation and its relationship with the risk of osteoporosis: protocol for a multicentre prospective cohort study in China
  1. Jing Wang1,2,3,
  2. Bing Shu1,2,4,
  3. Chen-Guang Li1,2,
  4. Xing-Wen Xie5,
  5. De Liang6,
  6. Bo-Lai Chen7,
  7. Xin-Chao Lin8,
  8. Xu Wei9,
  9. Liang Wang10,
  10. Xiang-Yang Leng11,
  11. Ying-Jie Zhou12,
  12. Pei-Zhan Chen13,
  13. Yu-Ren Tao1,2,
  14. Yong Zhou14,
  15. Yan Zhang1,2,4,
  16. Xue-Jun Cui1,2,
  17. Sheng Lu1,2,4,
  18. Hui Wang15,
  19. Qi Shi1,2,
  20. Yong-Jun Wang1,2,4,16
  1. 1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
  2. 2Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China
  3. 3Shanghai Geriatric Institute of Chinese Medicine, Shanghai, China
  4. 4Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
  5. 5Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China
  6. 6The First Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine, Guangzhou, China
  7. 7Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China
  8. 8Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
  9. 9Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China
  10. 10The 309th Hospital of Chinese People's Liberation Army, Beijing, China
  11. 11Hospital Affiliated to Changchun University of Traditional Chinese Medicine, Changchun, China
  12. 12Luoyang Zhenggu Hospital of Henan Province, Luoyang, China
  13. 13Clinical Research Center, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  14. 14Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
  15. 15School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  16. 16University of Traditional Chinese Medicine, Shanghai, China
  1. Correspondence to Dr Yong-Jun Wang; yjwang8888{at}126.com

Abstract

Introduction Osteoporotic fracture is one of the most common causes of disability and a major contributor to medical care costs in many regions of the world. The polymorphisms of genes related to vitamin D metabolism and transportation are associated with variation in bone mineral density and the risk of osteoporosis.

Methods and analysis The China Community-based Cohort of Osteoporosis study is an observational, longitudinal, multicentre, prospective cohort study for middle-aged and older permanent residents of China, which has been ongoing in six cities since 2016. Female residents aged 45–80 years old and male residents aged 50–80 years old are identified through permanent resident lists. All the enrolled participants will complete questionnaires on their personal characteristics and histories. The bone mineral density of their lumbar vertebrae and left hip will be measured and serum bone metabolism parameters assessed. Polymorphisms of genes related to vitamin D metabolism and transportation will be detected, and their relationship with the risk of osteoporosis, and osteoporotic fracture, will be analysed. About 18 000 residents will be involved in the study.

Ethics and dissemination The study was approved by Institutional Ethics Board of Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine (2016LCSY065). Results will be published in peer-reviewed journals. The results of this study are expected to improve the understanding of the association between polymorphisms of genes related to vitamin D metabolism and transportation and the risk of osteoporosis and osteoporotic fracture among middle-aged and older residents of China.

Trial registration number NCT02958020

  • cohort study
  • osteoporosis
  • China
  • protocol
  • vitamin D gene polymorphism

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Footnotes

  • Contributors Y-JW and QS conceived the review. JW, BS, YZ, X-JC, X-WX, DL, B-LC, X-CL, XW, LW, X-YL, Y-JZ, P-ZC, Y-RT, C-GL and SL performed clinical investigation. JW and YZ undertook the analyses. JW and BS wrote the initial draft. Y-JW and HW critically revised the manuscript.

  • Funding This study was funded by the National Key R&D Program of China (2018YFC1704300), National Nature Science Foundation of China (81730107 to Y-JW, 81673991 to BS and 81574001 to C-GL), Shanghai TCM Medical Center of Chronic Disease (2017ZZ01010 to Y-JW), National Clinical research base of TCM project (JDZX2015075 to C-GL, JDZX2015076 to XW, JDZX2015077 to X-YL, JDZX2015078 to DL, JDZX2015079 to X-CL, JDZX2015080 to X-WX, JDZX2015081 to B-LC, JDZX2015082 to Y-JZ), the Program for Innovative Research Team of Ministry of Education of China (IRT1270 to Y-JW), the Program for Innovative Research Team, Ministry of Science and Technology of the People’s Republic of China (2015RA4002 to Y-JW), Three Years Action to Accelerate the Development of Traditional Chinese Medicine Plan (ZY(2018-2020)-CCCX-3003 to Y-JW) and Guanghua Excellent PI Team (2016-06 to Y-JW).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The study was approved by the Institutional Review Board at Longhua Hospital affiliated to the Shanghai University of Traditional Chinese Medicine (2016LCSY065).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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