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Acupuncture methods for acute migraine attack: a Bayesian network meta-analysis protocol
  1. Jing Zhou1,
  2. Junlong Li1,
  3. Jiwei Yang1,
  4. Jianliang Li2,
  5. Chongxin Wang1
  1. 1 Aupuncture and Moxibustion Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
  2. 2 Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
  1. Correspondence to Dr Chongxin Wang; 963272568{at}


Introduction Migraine is a primary cause of disability worldwide, particularly affecting young adults and middle-aged women. Although multiple clinical trials and systematic reviews have suggested that acupuncture could be effective in treating acute migraine attacks, the methodologies in academic studies and commonly applied practices vary greatly. This study protocol outlines a plan to assess and rank the effectiveness of the different acupuncture methods in order to develop a prioritised acupuncture-based treatment regimen for acute migraine attacks.

Objective To compare the efficacy of different acupuncture methods and conventional medicinal methods in the treatment of acute migraine attacks.

Methods and analysis Six databases will be searched, including MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database and Wanfang Database from inception to 31 August 2019. The primary outcomes will be assessed using metrics for intensity and duration (in hours) of pain post-treatment. Bayesian network meta-analysis will be conducted using WinBUGS V.1.4.3. Finally, we will use the Grading of Recommendations Assessment, Development and Evaluation System to assess the quality of evidence.

Ethics and dissemination The results will be disseminated through peer-reviewed publication. Since no private and confidential patient data will be contained in the reporting, there are no ethical considerations associated with this protocol.

PROSPERO registration number CRD42019126472.

  • migraine disorders
  • acupuncture
  • network meta-analysis
  • systematic review
  • protocol

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  • Contributors JZ and CW conceived the study and drafted the protocol. JuL, JiL and JY revised it. JZ, JuL and JiL developed the search strategies and will run it. JZ and JuL will select studies and extract data. JZ and JY will analyse the data. All authors have approved the final edition of the protocol.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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