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Evaluating the efficacy of Internet-Based Exercise programme Aimed at Treating knee Osteoarthritis (iBEAT-OA) in the community: a study protocol for a randomised controlled trial
  1. Sameer Akram Gohir1,
  2. Paul Greenhaff1,2,3,4,5,
  3. Abhishek Abhishek1,6,
  4. Ana M. Valdes1
  1. 1NIHR Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, East Midland, UK
  2. 2Division of Physiology, Pharmacology and Neuroscience, University of Nottingham School of Medical and Surgical Sciences, Nottingham, Nottingham, UK
  3. 3MRC Arthritis Research UK Centre, MSK Ageing Research, Nottingham, United Kingdom
  4. 4School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
  5. 5NIHR Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom
  6. 6Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
  1. Correspondence to Sameer Akram Gohir; sameer.gohir{at}nottingham.ac.uk

Abstract

Introduction Knee osteoarthritis (OA) is the most common joint disease worldwide. As of today, there are no disease-modifying drugs, but there is evidence that muscle strengthening exercises can substantially reduce pain and improve function in this disorder, and one very well tested physiotherapy protocol is the ‘Better Management of Patients with Osteoarthritis’ developed in Sweden. Given the high prevalence of knee OA, a potentially cost-effective, digitally delivered approach to treat knee OA should be trialled. This study aims to explore the benefits of iBEAT-OA (Internet-Based Exercise programme Aimed at Treating knee Osteoarthritis) in modulating pain, function and other health-related outcomes in individuals with knee OA.

Methods and analysis A randomised controlled trial was designed to evaluate the efficacy of a web-based exercise programme in a population with knee OA compared with standard community care provided by general practitioners (GPs) in the UK. We anticipate recruiting participants into equal groups. The intervention group (n=67) will exercise for 20–30 min daily for six consecutive weeks, whereas the control group (n=67) will follow GP-recommended routine care. The participants will be assessed using a Numerical Rating Scale, the Western Ontario and McMaster Universities Osteoarthritis Index, the Arthritis Research UK Musculoskeletal Health Questionnaire, the Pittsburgh Sleep Quality Index, 30 s sit to stand test, timed up and go test, quantitative sensory testing, musculoskeletal ultrasound scan, muscle thickness assessment of the vastus lateralis, and quadriceps muscles force generation during an isokinetic maximum voluntary contraction (MVC). Samples of urine, blood, faeces and synovial fluid will be collected to establish biomarkers associated with changes in pain and sleep patterns in individuals affected with knee OA. Standard parametric regression methods will be used for statistical analysis.

Ethics and dissemination Ethical approval was obtained from the Research Ethics Committee (ref: 18/EM/0154) and the Health Research Authority (protocol no: 18021). The study was registered in June 2018. The results of the trial will be submitted for publication in a peer-reviewed journal.

Trial registration number NCT03545048

  • knee osteoarthritis
  • web based intervention
  • iBEAT-OA
  • knee pain

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Footnotes

  • Twitter @sameer_vicky

  • Contributors SG is the primary author and all other authors are secondary. AMV is the main supervisor and is leading this project. PG and AA are secondary supervisors. All authors have equally contributed to this article.

  • Funding This study is part-funded by the Pain Centre Versus UK (University of Nottingham) [Grant numbers 21960, 18769] and by Nottingham Biomedical Research Centre (BRC).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The study has received approval from the Research Ethics Committee (REC) (ref: 18/EM/0154), Health Research Authority (HRA) (protocol no: 18021) and the Nottingham University Hospitals NHS Trust Research & Innovation (R&I) department (ref: 18RH004). Any modification to the approved protocol will require resubmission of modifications and further approval from the REC and the sponsor.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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