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Sports and exercise medicine
Protocol
Effects of physical activity and sedentary behaviour on cardiometabolic risk factors and cognitive function in children: protocol for a cohort study
  1. Yajie Lv1,
  2. Li Cai1,
  3. Zhaohuan Gui1,
  4. Xia Zeng1,
  5. Minyi Tan1,
  6. Nianqing Wan1,
  7. Lijuan Lai1,
  8. Shaomin Lu2,
  9. Weiqing Tan3,
  10. Yajun Chen1
  1. 1Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
  2. 2Department of Child Health, Guangzhou Women and Children's Medical Center, Guangzhou, China
  3. 3Health Promotion Center for Primary and Secondary Schools of Guangzhou Municipality, Guangzhou, China
  1. Correspondence to Dr Yajun Chen; chenyj68{at}mail.sysu.edu.cn

Abstract

Introduction Although studies showed that physical activity (PA) and sedentary behaviour (SB) were associated with cardiometabolic risk factors and cognitive function, both independent and combined associations among them are inconsistent. Cardiometabolic risk factors are also associated with cognitive function, but research of children is limited. Additionally, the brain level mechanisms have not been fully established. The proposed study aims to explore the associations and mechanisms of PA and SB on cognitive function and cardiometabolic risk factors in children.

Methods and analysis This is a school-based prospective cohort study. A total of 8324 participants of this study are primary school students aged 7–12 years old who are followed up every 2 years from January 2017 to December 2026. We used a stratified cluster random sampling to select five primary schools in Guangzhou, China. There are three phases at baseline. At phase I, we collect PA, SB and cognitive function by questionnaires and also conduct anthropometric and biochemical measurements in all participants. At phase II, PA, SB and cognitive function are measured respectively by accelerometers and cognitive tasks among participants randomly selected from four subgroups with different SB and PA levels. At phase III, event-related potentials are recorded using electroencephalogram during a cognitive task among participants randomly selected from phase II. We plan to follow-up all participants until they graduate from high school. The process applied at baseline and follow-up are approximately identical.

Ethics and dissemination Procedures described in this manuscript have been approved by the Ethical Review Committee for Biomedical Research, School of Public Health, Sun Yat-sen University (L2016-010). All parents or guardians of participants signed the informed consent form voluntarily before participating in the study. The findings of the study will be published in peer-reviewed journals.

Trial registration number NCT03582709

  • cardio-metabolic risk factors
  • children
  • cognitive function
  • physical activity
  • sedentary behaviour

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2019-030322

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    Footnotes

    • Contributors YL is the first author. LC and YC obtained funding. LC, ZG, XZ and YL designed the study. YL, LC, ZG, XZ, MT, NW, LL, SL and WT collected the data. YL drafted the manuscript. LC and YC contributed to the interpretation of the results and critical revision of the manuscript for important intellectual content and approved the final version of the manuscript. All authors have read and approved the final manuscript. YC is the study guarantor.

    • Funding This study is supported by the National Natural Science Foundation of China (Grant No. 81673193).

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Ethics approval Procedures described in this manuscript have been approved by the Ethical Review Committee for Biomedical Research, School of Public Health, Sun Yat-sen University (L2016-010).

    • Provenance and peer review Not commissioned; externally peer reviewed.