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Research protocol for mechanical complications after central venous catheterisation: a prospective controlled multicentre observational study to determine incidence and risk factors of mechanical complications within 24 hours after cannulation
  1. Maria Adrian1,2,
  2. Ola Borgquist1,2,
  3. Peter Bentzer2,3,
  4. Jonas Åkeson2,4,
  5. Martin Spångfors2,5,
  6. Jonas Wrigstad6,7,
  7. Anders Holmström2,4,
  8. Rikard Linnér2,8,
  9. Thomas Kander1,2
  1. 1Department of Intensive and Perioperative Care, Skane University Hospital Lund, Lund, Sweden
  2. 2Department of Clinical Sciences, Anaesthesiology and Intensive Care, Lund University, Lund, Sweden
  3. 3Department of Anaesthesiology and Intensive Care, Helsingborg Hospital, Helsingborg, Sweden
  4. 4Department of Intensive and Perioperative Care, Skane University Hospital Malmo, Malmo, Sweden
  5. 5Department of Anaesthesiology and Intensive Care, Central Hospital Kristianstad, Kristianstad, Sweden
  6. 6Department of Paediatric Anaesthesiology and Intensive Care, Skanes University Hospital Lund, Lund, Sweden
  7. 7Department of Clinical Sciences, Surgery and Public Health, Lund University, Lund, Sweden
  8. 8Department of Cardiothoracic and Vascular Surgery, Skane University Hospital Lund, Lund, Sweden
  1. Correspondence to Dr Maria Adrian; maria.adrian{at}med.lu.se

Abstract

Introduction Central venous catheterisation is a common procedure in intensive care therapy and the use of central venous catheters is essential for treatment of many medical disorders. Although rare, central venous catheterisation is associated with mechanical complications that can be life-threatening if untreated. Real-time ultrasound guidance reduces the incidence of mechanical complications when compared with the anatomic landmark method. The purpose of this study is to determine the incidence of and potential risk factors associated with early mechanical complications of central venous catheterisation in an era where real-time ultrasound guidance has become clinical practice.

Methods and analysis This is a prospective, controlled, multicentre, observational study. All participating hospitals follow the same clinical guidelines for central venous catheterisation. Each central venous catheter insertion will be recorded in the common electronic chart system according to a recently revised template. An automated script-based search will identify all recorded central venous catheter insertion templates during the study period and relevant variables will be extracted. Outcome measures and independent variables are pre-defined in this study protocol. Multivariable and univariable logistic regression analysis will be used to determine associations and risk factors of mechanical complications.

Ethics and dissemination The Regional Ethical Review Board in Lund, Sweden has approved this study. The results will be submitted for publication in peer-reviewed medical journals and presented at national and international scientific meetings.

Trial registration number NCT03782324.

  • central venous catheterisation
  • complications
  • internal jugular vein
  • subclavian vein
  • femoral vein

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Footnotes

  • Contributors TK was the originator of the study. MA, OB and TK designed the study. MA wrote the first version of the manuscript. MA, OB, TK, PB, JÅ, MS, JW, AH and RL contributed to the study design and revised the manuscript critically. All authors gave final approval of the version to be published.

  • Funding The Department of Quality Management, Region Skåne, supported this work.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This prospective controlled multicentre observational study was approved by the Regional Ethical Review Board in Lund, Sweden (Dnr 2018/295) and registered as a clinical trial with ClinicalTrials.gov (identifier: NCT03782324).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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