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Association of high-sensitivity C-reactive protein in middle-aged and elderly Chinese people with hyperuricaemia and risk of coronary heart disease: a cross-sectional study
  1. Mingsheng Xie1,
  2. Dongxing Xie1,
  3. Ye Yang1,
  4. Yi Zhang1,
  5. Kun Li1,
  6. Bin Zhou1,
  7. Zidan Yang2,
  8. Xiang Ding1,
  9. Hui Li1,3,4
  1. 1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China
  2. 2 Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China
  3. 3 Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China
  4. 4 National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
  1. Correspondence to Dr Hui Li; lihui1988{at}; Dr Xiang Ding; dingxiang{at}


Objectives Patients with hyperuricaemia are at relatively high risk of developing coronary heart disease (CHD). The purpose of this study was to examine the relationship between high-sensitivity C-reactive protein (hs-CRP) and CHD risk in a middle-aged and elderly population with hyperuricaemia.

Design A cross-sectional study.

Setting and participants This study was conducted in a health examination centre of China. Participants were diagnosed with hyperuricaemia based on uric acid concentrations. Specifically, males with a uric acid concentration ≥416 μmol/L were included, as well as females with a concentration ≥360 μmol/L.

Main outcome measures 10-year CHD risk for each individual was evaluated using Framingham risk score based on the Adult Treatment Panel III charts.

Results A total of 517 patients with hyperuricaemia (438 males and 79 females) aged from 40 to 85 years old were included in the present study. 193 (37.3%) patients were defined with relatively high 10-year CHD risk. Compared with the lowest quintile, the crude ORs of relatively high 10-year CHD risks were 1.43 (95% CI 0.78 to 2.63, p=0.245), 2.05 (95% CI 1.14 to 3.67, p=0.016), 2.77 (95% CI 1.54 to 4.98, p=0.001), 2.12 (95% CI 1.18 to 3.80, p=0.012) in the second, third, fourth and fifth quintiles of serum hs-CRP level, respectively (p for trend=0.057). The multivariable-adjusted ORs of relatively high 10-year CHD risk were 1.40 (95% CI 0.75 to 2.61, p=0.291) in the second, 2.05 (95% CI 1.13 to 3.72, p=0.019) in the third, 2.69 (95% CI 1.47 to 4.89, p=0.001) in the fourth and 2.10 (95% CI 1.15 to 3.84, p=0.016) in the fifth quintile of serum hs-CRP level when compared with the lowest quintile (p for trend=0.068).

Conclusion This study showed that ORs of relatively high 10-year CHD risk were raised in patients with hyperuricaemia with higher serum hs-CRP level; however, there was a not significant but borderline trend association and that more research is needed.

  • hyperuricemia
  • high-sensitivity C-reactive protein
  • coronary heart disease

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  • MX and DX contributed equally.

  • XD and HL contributed equally.

  • Contributors MX, DX, HL and XD were responsible for the conception and design of the study. KL, BZ and ZY contributed to the statistical analyses. MX, DX, HL, XD, YY and YZ contributed to the data collection and interpretation. MX, DX, HL and XD drafted the manuscript. HL, XD and ZY contributed to the revision of the manuscript. All authors read and approved the final manuscript.

  • Funding This work was supported by the National Natural Science Foundation of China (81772413, 81702207, 81702206), the Young Investigator Grant of Xiangya Hospital, Central South University (2017Q10) and the Postgraduate Independent Exploration and Innovation Project of Central South University (2018zzts256).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This study was approved by the ethics committee of Xiangya Hospital, Central South University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement No data are available.

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