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Intensive care
Protocol
Long-term follow-up for Psychological stRess in Intensive CarE (PRICE) survivors: study protocol for a multicentre, prospective observational cohort study in Australian intensive care units
  1. Sumeet Rai1,2,
  2. Rhonda Brown3,
  3. Frank van Haren1,4,
  4. Teresa Neeman5,
  5. Arvind Rajamani6,7,
  6. Krishnaswamy Sundararajan8,9,
  7. Imogen Mitchell1,2
  1. 1 Intensive Care Unit, Canberra Hospital, Canberra, Australian Capital Territory, Australia
  2. 2 Medical School, Australian National University, Canberra, Australian Capital Territory, Australia
  3. 3 Research School of Psychology, Australian National University, Canberra, Australian Capital Territory, Australia
  4. 4 Faculty of Health, University of Canberra, Canberra, Australian Capital Territory, Australia
  5. 5 Statistical Consulting Unit, Australian National University, Canberra, Australian Capital Territory, Australia
  6. 6 Intensive Care Unit, Nepean Hospital, Penrith, New South Wales, Australia
  7. 7 Discipline of Critical Care, Nepean Clinical School, University of Sydney, Sydney, New South Wales, Australia
  8. 8 Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
  9. 9 Discipline of Acute Care Medicine, University of Adelaide, Adelaide, South Australia, Australia
  1. Correspondence to Dr Sumeet Rai; sumeet.rai{at}act.gov.au

Abstract

Introduction There are little published data on the long-term psychological outcomes in intensive care unit (ICU) survivors and their family members in Australian ICUs. In addition, there is scant literature evaluating the effects of psychological morbidity in intensive care survivors on their family members. The aims of this study are to describe and compare the long-term psychological outcomes of intubated and non-intubated ICU survivors and their family members in an Australian ICU setting.

Methods and analysis This will be a prospective observational cohort study across four ICUs in Australia. The study aims to recruit 150 (75 intubated and 75 non-intubated) adult ICU survivors and 150 family members of the survivors from 2015 to 2018. Long-term psychological outcomes and effects on health-related quality of life (HRQoL) will be evaluated at 3 and 12 months follow-up using validated and published screening tools. The primary objective is to compare the prevalence of affective symptoms in intubated and non-intubated survivors of intensive care and their families and its effects on HRQoL. The secondary objective is to explore dyadic relations of psychological outcomes in patients and their family members.

Ethics and dissemination The study has been approved by the relevant human research ethics committees (HREC) of Australian Capital Territory (ACT) Health (ETH.11.14.315), New South Wales (HREC/16/HNE/64), South Australia (HREC/15/RAH/346). The results of this study will be published in a peer-reviewed medical journal and presented to the local intensive care community and other stakeholders.

Trial registration number ACTRN12615000880549; Pre-results.

  • psychological
  • long-term outcomes

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2018-023310

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    Footnotes

    • Patient consent for publication Not required.

    • Twitter @docsrai

    • Contributors SR is the chief investigator of the multicenter study, PRICE.SR, RB, IM wrote the first draft of the manuscript.SR, RB, FVH, TN, KS, AR, IM all contributed to the study design.SR, IM were co-applicants on the ACT Health Private Practice Fund grant.KS, SR were co-applicants on the Maurice Sando Foundation Sponsorhip Scheme. All authors have critically evaluated and approved the manuscript.

    • Funding This work was supported by the ACT Health Private Practice Fund and Maurice Sando Foundation Sponsorship Scheme 2015 by a local competitive grant process.

    • Competing interests None declared.

    • Ethics approval The study has been approved by the relevant human research ethics committees (HREC) of Australian Capital Territory (ACT) Health (ETH.11.14.315), New South Wales (HREC/16/HNE/64), South Australia (HREC/15/RAH/346). Individual hospitals will obtain approval from their local site-specific governance committees.

    • Provenance and peer review Not commissioned; externally peer reviewed.