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Use of isotretinoin and risk of depression in patients with acne: a systematic review and meta-analysis
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- Published on: 27 February 2022
- Published on: 27 February 2022Masking of Risk for a Minority
As recently reported (1), we wonder whether improvement of quality of life for a majority of people (benefiting from the medication) can dilute or completely mask a drastic deterioration of mood in a significant minority? This might explain conflicting data in the literature as expressed in the “highly significant heterogeneity” found in the above systematic review.
Mayer Brezis, MD MPH, Professor of Medicine (Emeritus), Hebrew University, Jerusalem, Israel
Former Director of the Center for Clinical Quality & Safety, Hadassah Medical Center1. Baldessarini, R.J. and Pompili, M., 2021. Further Studies of Effects of Finasteride on Mood and Suicidal Risk. Journal of clinical psychopharmacology, 41(6), pp.687-688.
Conflict of Interest:
None declared.