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As recently reported (1), we wonder whether improvement of quality of life for a majority of people (benefiting from the medication) can dilute or completely mask a drastic deterioration of mood in a significant minority? This might explain conflicting data in the literature as expressed in the “highly significant heterogeneity” found in the above systematic review.
Mayer Brezis, MD MPH, Professor of Medicine (Emeritus), Hebrew University, Jerusalem, Israel
Former Director of the Center for Clinical Quality & Safety, Hadassah Medical Center
1. Baldessarini, R.J. and Pompili, M., 2021. Further Studies of Effects of Finasteride on Mood and Suicidal Risk. Journal of clinical psychopharmacology, 41(6), pp.687-688.