OPtimising Treatment for MIld Systolic hypertension in the Elderly (OPTiMISE): protocol for a randomised controlled non-inferiority trial

James P Sheppard; Jenni Burt; Mark Lown; Eleanor Temple; John Benson; Gary A Ford; Carl Heneghan; F D Richard Hobbs; Sue Jowett; Paul Little; Jonathan Mant; Jill Mollison; Alecia Nickless; Emma Ogburn; Rupert Payne; Marney Williams; Ly-Mee Yu; Richard J McManus

doi:10.1136/bmjopen-2018-022930

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General practice / Family practice

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OPtimising Treatment for MIld Systolic hypertension in the Elderly (OPTiMISE): protocol for a randomised controlled non-inferiority trial

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James P Sheppard Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Jenni Burt The Healthcare Improvement Studies Institute, University of Cambridge, Cambridge, UK PubMed articles Google scholar articles
Mark Lown Primary Care Research Group, University of Southampton, Southampton, UK PubMed articles Google scholar articles
Eleanor Temple Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK PubMed articles Google scholar articles
John Benson Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK PubMed articles Google scholar articles
Gary A Ford Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Carl Heneghan Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK PubMed articles Google scholar articles
F D Richard Hobbs Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Sue Jowett Institute of Applied Health Research, University of Birmingham, Birmingham, UK PubMed articles Google scholar articles
Paul Little Primary Care Research Group, University of Southampton, Southampton, UK PubMed articles Google scholar articles
Jonathan Mant Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK PubMed articles Google scholar articles
Jill Mollison Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Alecia Nickless Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Emma Ogburn Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Rupert Payne Centre for Academic Primary Care, University of Bristol, Bristol, UK PubMed articles Google scholar articles
Marney Williams Patient and Public Involvement Representative, London, UK PubMed articles Google scholar articles
Ly-Mee Yu Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Richard J McManus Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK PubMed articles Google scholar articles

Correspondence to Dr James P Sheppard; james.sheppard{at}phc.ox.ac.uk

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Sheppard JP, Burt J, Lown M, et al

OPtimising Treatment for MIld Systolic hypertension in the Elderly (OPTiMISE): protocol for a randomised controlled non-inferiority trial

BMJ Open 2018;8:e022930. doi: 10.1136/bmjopen-2018-022930

Publication history

Received March 13, 2018
Revised August 10, 2018
Accepted August 18, 2018
First published October 4, 2018.

Online issue publication

January 10, 2022

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© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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