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Systematic bias between blinded independent central review and local assessment: literature review and analyses of 76 phase III randomised controlled trials in 45 688 patients with advanced solid tumour

Authors

  • Jianrong Zhang Department of Thoracic Surgery and Oncology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, China National Clinical Research Centre of Respiratory Disease, Guangzhou, China George Warren Brown School, Washington University in St. Louis, St. Louis, Missouri, USA PubMed articlesGoogle scholar articles
  • Yiyin Zhang Nanshan School, Guangzhou Medical University, Guangzhou, China Department of Pancreatic Surgery/Oncology, Fudan University Shanghai Cancer Center, Shanghai, China Pancreatic Cancer Institute, Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Shiyan Tang Nanshan School, Guangzhou Medical University, Guangzhou, China Department of Surgery and Cancer, Imperial College London, London, UK PubMed articlesGoogle scholar articles
  • Long Jiang Department of Thoracic Surgery and Oncology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, China National Clinical Research Centre of Respiratory Disease, Guangzhou, China PubMed articlesGoogle scholar articles
  • Qihua He Department of Thoracic Surgery and Oncology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, China National Clinical Research Centre of Respiratory Disease, Guangzhou, China PubMed articlesGoogle scholar articles
  • Lindsey Tristine Hamblin Department of Thoracic Surgery and Oncology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Institute of International Education, Guangdong University of Foreign Studies, Guangzhou, China PubMed articlesGoogle scholar articles
  • Jiaxi He Department of Thoracic Surgery and Oncology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, China National Clinical Research Centre of Respiratory Disease, Guangzhou, China PubMed articlesGoogle scholar articles
  • Zhiheng Xu Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, China National Clinical Research Centre of Respiratory Disease, Guangzhou, China PubMed articlesGoogle scholar articles
  • Jieyu Wu Department of Pathology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden PubMed articlesGoogle scholar articles
  • Yaoqi Chen Department of Thoracic Surgery and Oncology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, China National Clinical Research Centre of Respiratory Disease, Guangzhou, China PubMed articlesGoogle scholar articles
  • Hengrui Liang Nanshan School, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Difei Chen Nanshan School, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Yu Huang Nanshan School, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Xinyu Wang Nanshan School, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Kexin Deng Nanshan School, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Shuhan Jiang Nanshan School, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Jiaqing Zhou Nanshan School, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Jiaxuan Xu Nanshan School, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Xuanzuo Chen Nanshan School, Guangzhou Medical University, Guangzhou, China PubMed articlesGoogle scholar articles
  • Wenhua Liang Department of Thoracic Surgery and Oncology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, China National Clinical Research Centre of Respiratory Disease, Guangzhou, China PubMed articlesGoogle scholar articles
  • Jianxing He Department of Thoracic Surgery and Oncology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, China National Clinical Research Centre of Respiratory Disease, Guangzhou, China PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Wenhua Liang; liangwh1987{at}163.com and Dr Jianxing He; drjianxing.he{at}gmail.com
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Citation

Zhang J, Zhang Y, Tang S, et al
Systematic bias between blinded independent central review and local assessment: literature review and analyses of 76 phase III randomised controlled trials in 45 688 patients with advanced solid tumour

Publication history

  • Received April 10, 2017
  • Revised April 11, 2018
  • Accepted July 24, 2018
  • First published September 10, 2018.
Online issue publication 
September 10, 2018

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