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Epidemiology
Protocol
Validating injury burden estimates using population birth cohorts and longitudinal cohort studies of injury outcomes: the VIBES-Junior study protocol
  1. Belinda J Gabbe1,2,3,
  2. Joanna F Dipnall1,4,
  3. John W Lynch5,6,
  4. Frederick P Rivara7,
  5. Ronan A Lyons2,3,
  6. Shanthi Ameratunga8,
  7. Mariana Brussoni9,10,
  8. Fiona E Lecky11,
  9. Clare Bradley12,13,
  10. Pam M Simpson1,
  11. Ben Beck1,
  12. Joanne C Demmler2,
  13. Jane Lyons2,
  14. Amy Schneeberg10,14,
  15. James E Harrison15
  1. 1 School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
  2. 2 Health Data Research UK, Swansea University, Swansea, UK
  3. 3 National Centre for Population Health and Wellbeing Research, Swansea University, Swansea, UK
  4. 4 School of Medicine, Deakin University, Geelong, Victoria, Australia
  5. 5 School of Public Health, University of Adelaide, Adelaide, South Australia, Australia
  6. 6 School of Population Health Sciences, University of Bristol, Bristol, UK
  7. 7 Departments of Pediatrics and Epidemiology, and the Harborview Injury Prevention and Research Center, University of Washington, Seattle, Washington, USA
  8. 8 School of Population Health, University of Auckland, Auckland, New Zealand
  9. 9 Department of Pediatrics, School of Population and Public Health, University of British Columbia, Vancouver, Canada
  10. 10 British Columbia Injury Research and Prevention Unit, Children’s Hospital Research Institute, Vancouver, Canada
  11. 11 School of Health and Related Research, University of Sheffield, Sheffield, UK
  12. 12 South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia
  13. 13 School of Medicine, Flinders University, Adelaide, South Australia, Australia
  14. 14 School of Population and Public Health, University of British Columbia, Vancouver, Canada
  15. 15 Research Centre for Injury Studies, Flinders University, Adelaide, South Australia, Australia
  1. Correspondence to Dr Belinda J Gabbe; belinda.gabbe{at}monash.edu

Abstract

Introduction Traumatic injury is a leading contributor to the global disease burden in children and adolescents, but methods used to estimate burden do not account for differences in patterns of injury and recovery between children and adults. A lack of empirical data on postinjury disability in children has limited capacity to derive valid disability weights and describe the long-term individual and societal impacts of injury in the early part of life. The aim of this study is to establish valid estimates of the burden of non-fatal injury in children and adolescents.

Methods and analysis Five longitudinal studies of paediatric injury survivors <18 years at the time of injury (Australia, Canada, UK and USA) and two whole-of-population linked administrative data paediatric studies (Australia and Wales) will be analysed over a 3-year period commencing 2018. Meta-analysis of deidentified patient-level data (n≈2,600) from five injury-specific longitudinal studies (Victorian State Trauma Registry; Victorian Orthopaedic Trauma Outcomes Registry; UK Burden of Injury; British Columbia Children’s Hospital Longitudinal Injury Outcomes; Children’s Health After Injury) and >1 million children from two whole-of-population cohorts (South Australian Early Childhood Data Project and Wales Electronic Cohort for Children). Systematic analysis of pooled injury-specific cohort data using a variety of statistical techniques, and parallel analysis of whole-of-population cohorts, will be used to develop estimated disability weights for years lost due to disability, establish appropriate injury classifications and explore factors influencing recovery.

Ethics and dissemination The project was approved by the Monash University Human Research Ethics Committee project number 12 311. Results of this study will be submitted for publication in internationally peer-reviewed journals. The findings from this project have the capacity to improve the validity of paediatric injury burden measurements in future local and global burden of disease studies.

  • epidemiology
  • paediatrics
  • public health
  • trauma management

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2018-024755

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    Footnotes

    • Contributors All authors are investigators of the project, contributed to the study design and funding application. BJG drafted the manuscript. JFD, JL, FPR, RAL, SA, MB, FEL, CB, PMS, BB, JCD, JL, AS and JEH reviewed the manuscript and approved the final version of the manuscript.

    • Funding The VIBES-Junior project is funded by the National Health and Medical Research Council of Australia project grant (APP1142325). The UKBOI study was funded by the Policy Research Programme in the Department of Health (Grant number: 0010009). The VSTR is a Department of Health (Victoria) and Transport Accident Commission (TAC) funded initiative. VOTOR is funded by the TAC through the Institute for Safety, Compensation and Recovery Research. The SAECDP is funded by NHMRC Partnership Project Grant (1056888), NHMRC Centre of Research Excellence (1099422) and the Government of South Australia. The CHAI project was funded by a grant from the US Centers for Disease Control and Prevention. WECC is funded through Health and Care Research Wales and Health Data Research UK. The BCCH-LIO was funded by the Canadian Institutes of Health Research (Grant #TIR-104028) and the Michael Smith Foundation for Health Research. Salary support for MB was provided by the BCCH Research Institute and by a Michael Smith Foundation for Health Research Scholar Award. BJG was supported by an Australian Research Council Future Fellowship (FT170100048).

    • Competing interests None declared.

    • Patient consent Not required.

    • Ethics approval The project was approved by the Monash University Human Research Ethics Committee project number 12311.

    • Provenance and peer review Not commissioned; peer reviewed for ethical and funding approval prior to submission.