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Perioperative urinary thromboxane metabolites and outcome of coronary artery bypass grafting: a nested case-control study
  1. Hanning Liu1,
  2. Zhengxi Xu1,
  3. Cheng Sun1,
  4. Qianlong Chen1,2,
  5. Ning Bao1,
  6. Wen Chen1,2,
  7. Zhou Zhou1,2,
  8. Xiaoqi Wang1,
  9. Zhe Zheng1
  1. 1 State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  2. 2 Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases, Fuwai Hospital, Beijing, China
  1. Correspondence to Dr Zhe Zheng; zhengzhe{at}fuwai.com

Abstract

Objective As a marker of in vivo thromboxane generation, high-level urinary thromboxane metabolites (TXA-M) increase the occurrence of cardiovascular events in high-risk patients. To investigate whether perioperative urinary TXA-M level is associated with major adverse cardiac and cerebrovascular events (MACCE) after coronary artery bypass graft (CABG) surgery, we designed a nested case-control study.

Design Observational, nested case-control study.

Setting Single-centre outcomes research in Fuwai Hospital, Beijing, China.

Participants One thousand six hundred and seventy Chinese patients undergoing CABG surgery from September 2011 to October 2013.

Methods We obtained urinary samples from 1670 Chinese patients undergoing CABG 1 hour before surgery (pre-CABG), and 6 hours (post-CABG 6 hours) and 24 hours after surgery (post-CABG 24 hours). Patients were followed up for 1 year, and we observed 56 patients had MACCE. For each patient with MACCE, we matched three control subjects. Perioperative urinary TXA-M of the three time spots was detected in these 224 patients.

Results Post-CABG 24 hours TXA-M is significantly higher than that of patients without MACCE (11 101vs8849 pg/mg creatine, P=0.007). In addition, patients in the intermediate tertile and upper tertile of post-CABG 24 hours urinary TXA-M have a 2.2 times higher (HR 2.22, 95% CI 1.04 to 4.71, P=0.038) and a 2.8 times higher (HR 2.81, 95% CI 1.35 to 5.85, P=0.006) risk of 1 year MACCE than those in the lower tertile, respectively.

Conclusions In conclusion, post-CABG 24 hours urinary TXA-M elevation is associated with an increase of 1 year adverse events after CABG, indicating that the induction of cyclo-oxygenase-2 by surgery-related inflammatory stimuli or platelet turnover may be responsible for the high levels of post-CABG urinary TXA-M.

Trial registration number NCT01573143.

  • coronary heart disease
  • coronary artery bypass grafting
  • urine thromboxane metabolites
  • major adverse cardiac and cerebrovascular events

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Footnotes

  • HL and ZX contributed equally.

  • ZZ, XW and ZZ contributed equally.

  • Contributors HL and ZX were involved in data collection, data analysis, writing of manuscript. CS and NB were involved in data verification. WC and QC were involved in the collection of patients’ urine and test of TXA-M in patients’ urine. ZhoZ, ZheZ and XW were involved in the design of study and student supervision, editing of manuscript.

  • Funding This study was supported by the Key Project in the National Science and Technology Pillar Programme during the 12th 5-year plan period (2013BAI09B01).

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval Review Board of Fuwai Hospital, Peking Union Medical College (Beijing, China)

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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