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Xylitol for the prevention of acute otitis media episodes in children aged 2–4 years: protocol for a pragmatic randomised controlled trial

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  • Nav Persaud Department of Family and Community Medicine, St Michael’s Hospital, Toronto, Ontario, Canada Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Andreas Laupacis Department of Family and Community Medicine, St Michael’s Hospital, Toronto, Ontario, Canada Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Amir Azarpazhooh Faculty of Dentistry, University of Toronto, Toronto, Canada Department of Dentistry, Mount Sinai Hospital, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Toronto Health Economics and Technology Assessment Collaborative, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Catherine Birken Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Department of Paediatrics, The Hospital for Sick Children (SickKids), University of Toronto, Toronto, Ontario, Canada The Applied Health Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada Pediatric Outcomes Research Team, Division of Pediatric Medicine, Department of Pediatrics, the, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Jeffrey S Hoch Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Department of Public Health Sciences, School of Medicine, University of California, Davis, California, USA Center for Health Policy and Research, University of California, Davis, California, USA Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada Department of Public Health Sciences, University of California, Davis, California, USA PubMed articlesGoogle scholar articles
  • Wanrudee Isaranuwatchai Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Centre for Excellence in Economic Analysis Research (CLEAR), St. Michael’s Hospital, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Jonathan L Maguire Department of Paediatrics, The Hospital for Sick Children (SickKids), University of Toronto, Toronto, Ontario, Canada The Applied Health Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada Paediatric Outcomes Research Team, The Hospital for Sick Children (SickKids), University of Toronto, Toronto, Ontario, Canada Department of Paediatrics, St Michael’s Hospital, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Muhammad M Mamdani Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada Department of Medicine, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada Centre for Healthcare Analytics Research and Training, St Michael’s Hospital, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Kevin Thorpe Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Christopher Allen The Applied Health Research Centre of the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Dalah Mason Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Christine Kowal Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Farnaz Bazeghi Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Patricia Parkin Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Department of Paediatrics, The Hospital for Sick Children (SickKids), University of Toronto, Toronto, Ontario, Canada Pediatric Outcomes Research Team, Division of Pediatric Medicine, Department of Pediatrics, the, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
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  1. Correspondence to Dr Nav Persaud; nav.persaud{at}utoronto.ca
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Citation

Persaud N, Laupacis A, Azarpazhooh A and The TARGet Kids! Collaboration, et al
Xylitol for the prevention of acute otitis media episodes in children aged 2–4 years: protocol for a pragmatic randomised controlled trial

Publication history

  • Received December 4, 2017
  • Revised April 20, 2018
  • Accepted June 21, 2018
  • First published August 5, 2018.
Online issue publication 
August 05, 2018

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