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  • Relation of serum uric acid to asymptomatic proximal extracranial artery stenosis in a middle-aged Chinese population: a community-based cross-sectional study

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Cardiovascular medicine
Research
Relation of serum uric acid to asymptomatic proximal extracranial artery stenosis in a middle-aged Chinese population: a community-based cross-sectional study
  1. Xiaolei Yang1,
  2. Haichen Lv1,
  3. Tesfaldet Habtemariam Hidru1,
  4. Jing Wu2,
  5. Henghui Liu2,
  6. Youxin Wang3,
  7. Kejia Liu2,
  8. Yunlong Xia1,
  9. Yong Zhou4,
  10. Yinong Jiang1
  1. 1 Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China
  2. 2 Department of Technology, Beijing Recdata Technology Co., Ltd, Beijing, China
  3. 3 Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China
  4. 4 Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vascular Diseases, Beijing, China
  1. Correspondence to Dr Yinong Jiang; yinongjiang{at}126.com

Abstract

Objective Serum uric acid (SUA) has been associated with cardiovascular diseases, including atherosclerosis and carotid artery stenosis. However, data on the relationship between SUA level and proximal extracranial artery stenosis (PEAS) are limited. Therefore, this study investigates the association between SUA levels and the risk of PEAS in asymptomatic Chinese population.

Setting This community-based cross-sectional study was conducted in Jidong Community Hospital, Tangshan, Hebei, China between July 2013 and August 2014.

Participants The study examined 3325 asymptomatic participants (40–60 years) to evaluate the risk of PEAS.

Results For the participants stratified into quartiles based on gender-specific SUA levels, the prevalence of PEAS increased from Q1 to Q4 from 12.3% to 29.8% in the vertebral artery (VA), and from 2.8% to 5.8% in the common carotid artery. The proportion of PEAS relative to the detected number of arterial stenosis was lower in Q1 than in Q2–Q4. The multivariable ORs and 95% CI of PEAS in the second through fourth compared with the lowest quartiles for arterial stenosis were 1.278 (0.980 to 1.665), 1.117 (0.851 to 1.468) and 1.375 (1.033 to 1.830) (ptrend=0.0399); and for VA stenosis, 1.285 (0.966 to 1.709), 1.085 (0.808 to 1.457) and 1.439 (1.061 to 1.952) (ptrend=0.0235).

Conclusion Elevated SUA concentration is significantly associated with PEAS in an asymptomatic middle-aged Chinese population, and vertebral arteries appeared to be the most vulnerable vessels.

  • uric acid
  • hyperuricemia
  • arterial stenosis
  • vertebral artery stenosis

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2017-020681

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    Footnotes

    • Contributors XY, HL, YJ and YZ designed research. XY, HL, JW, YJ and YX conducted research. XY, HL, HL, YW and KL analysed data. XY, HL and THH wrote the draft. All authors read, reviewed and approved the final manuscript. YJ and YZ are primary responsible for the final content.

    • Funding This study was supported by grants from the National Natural Science Foundation of China (No. 81570391), Capital Special Clinical Application Grants (Z141107002514103) and the Recovery Medical Science Foundation.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Ethics approval Ethical approval for the research protocol was approved by the Ethics Committee of Jidong Community Hospital and PERSUADE study prior to study initiation.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement No additional data are available.