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Are large randomised controlled trials in severe sepsis and septic shock statistically disadvantaged by repeated inadvertent underestimates of required sample size?

Authors

  • Joshua L C Wong Department of Surgery and Cancer, Section of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, UK PubMed articlesGoogle scholar articles
  • Alexina J Mason Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK PubMed articlesGoogle scholar articles
  • Anthony C Gordon Department of Surgery and Cancer, Section of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK PubMed articlesGoogle scholar articles
  • Stephen J Brett Department of Surgery and Cancer, Section of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Joshua L C Wong; joshua.wong{at}imperial.ac.uk
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Citation

Wong JLC, Mason AJ, Gordon AC, et al
Are large randomised controlled trials in severe sepsis and septic shock statistically disadvantaged by repeated inadvertent underestimates of required sample size?

Publication history

  • Received November 1, 2017
  • Revised June 6, 2018
  • Accepted June 8, 2018
  • First published August 29, 2018.
Online issue publication 
August 29, 2018

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