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Are large randomised controlled trials in severe sepsis and septic shock statistically disadvantaged by repeated inadvertent underestimates of required sample size?

 

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Aug 201814314321
Sep 201828928866
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Nov 201812612613
Dec 201816416412
Jan 201967685
Feb 2019696916
Mar 2019555513
Apr 2019606018
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Jan 2020454522
Feb 2020616111
Mar 202038386
Total18191818347