Article Text
Abstract
Objective To examine the role of the Five Factor Model (FFM) personality traits in reporting the development of adverse drug reactions (ADRs) when controlling for sociodemographic variables and health status.
Design Prospective cohort study.
Setting The Estonian Biobank of the Estonian Genome Centre, University of Tartu.
Participants 814 women and 543 men (mean age=47.9 years; SD=15.2) who after the initial enrolment in the Estonian Biobank were re-contacted for follow-up purposes about 5.3 years after the enrolment and for whom both self- and informant-reported personality data were available.
Main outcome measure Participants who did not report having any ADRs at baseline but who reported ADRs at the follow-up about 5.3 years later versus participants who did not report any ADRs at either time point. The reports of developing ADRs were predicted from the FFM personality traits after statistically controlling for sociodemographic variables (age, gender and education), baseline indicators of health status (number of diagnoses and medicines taken, body mass index and blood pressure), and the change in health status between the two measurements.
Results The results of a hierarchical binary logistic regression analysis showed that participants who reported the development of ADRs between the two measurements had higher levels of conscientiousness, were more likely to be women, were taking more medicines at baseline and had a higher increase in the number of medicines taken during the study period than participants who did not report any ADRs at either time point (all p values <0.05). Higher neuroticism (p=0.067) and a higher number of diagnosed diseases at baseline (p=0.053) also made marginal contributions to predicting the development of ADRs.
Conclusions This study shows for the first time that higher levels of conscientiousness and neuroticism are associated with reporting the development of ADRs.
- adverse drug reactions
- five-factor model personality traits
- prospective cohort study
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Footnotes
Contributors AR: conceived the study, prepared the data, and contributed to the analysis of data and writing of the manuscript. LK-A: helped with data preparation. AWME, HvM and JA: contributed to the interpretation of data and critically reviewed and commented on the manuscript. All authors reviewed and approved the final version of the manuscript.
Funding Preparation of this manuscript was supported by institutional research funding (IUT2-13) from the Estonian Ministry of Education and Science to JA and by the European Research Council Consolidator Grant to AWME (ERC-2013-CoG-617700).
Disclaimer The authors were completely independent from funders in conducting this study and writing this manuscript.
Competing interests None declared.
Patient consent Not required.
Ethics approval This research was approved by the Research Ethics Committee of the University of Tartu (approvals: 236/M-29, 14 May 2014; 206/T-4, 22 August 2011; 170/T-38, 28 April 2008; 166/T-21, 17 December 2007).
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement No additional data available. The data used for this research are available for scrutiny at the Estonian Genome Centre of the University of Tartu (EGCUT), but cannot be released because of the licensing conditions to which we are obliged to adhere.