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  • Protocol for a phase II, monocentre, double-blind, placebo-controlled, cross-over trial to assess efficacy of pyridostigmine in patients with spinal muscular atrophy types 2–4 (SPACE trial)

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Neurology
Protocol
Protocol for a phase II, monocentre, double-blind, placebo-controlled, cross-over trial to assess efficacy of pyridostigmine in patients with spinal muscular atrophy types 2–4 (SPACE trial)

Authors

  • Marloes Stam Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Renske I Wadman Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Camiel A Wijngaarde Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Bart Bartels Child Development and Exercise Center, Wilhelmina’s Children Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Fay-Lynn Asselman Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Louise A M Otto Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • H Stephan Goedee Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Laura E Habets Child Development and Exercise Center, Wilhelmina’s Children Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Janke F de Groot Child Development and Exercise Center, Wilhelmina’s Children Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands Netherlands Institute for Health Services Research (NIVEL), Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Marja A G C Schoenmakers Child Development and Exercise Center, Wilhelmina’s Children Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Inge Cuppen Department of Neurology and Child Neurology, Brain Center Rudolf Magnus, Wilhelmina’s Children Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Leonard H van den Berg Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • W Ludo van der Pol Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  1. Correspondence to Dr W Ludo van der Pol; W.L.vanderPol{at}umcutrecht.nl
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Citation

Stam M, Wadman RI, Wijngaarde CA, et al
Protocol for a phase II, monocentre, double-blind, placebo-controlled, cross-over trial to assess efficacy of pyridostigmine in patients with spinal muscular atrophy types 2–4 (SPACE trial)
BMJ Open 2018;8:e019932. doi: 10.1136/bmjopen-2017-019932

Publication history

  • Received October 4, 2017
  • Revised December 12, 2017
  • Accepted February 26, 2018
  • First published July 30, 2018.
Online issue publication 
January 10, 2022
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© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.