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Short-term abstinence from alcohol and changes in cardiovascular risk factors, liver function tests and cancer-related growth factors: a prospective observational study
  1. Gautam Mehta1,
  2. Stewart Macdonald1,
  3. Alexandra Cronberg2,
  4. Matteo Rosselli1,
  5. Tanya Khera-Butler2,
  6. Colin Sumpter2,
  7. Safa Al-Khatib1,
  8. Anjly Jain3,
  9. James Maurice1,
  10. Christos Charalambous1,
  11. Amir Gander4,
  12. Cynthia Ju5,
  13. Talay Hakan6,
  14. Roy Sherwood7,
  15. Devaki Nair8,
  16. Rajiv Jalan1,
  17. Kevin P Moore1
  1. 1 Division of Medicine, UCL Institute for Liver and Digestive Health, London, UK
  2. 2 Camden and Islington Public Health, London, UK
  3. 3 Department of Clinical Biochemistry, Royal Free London NHS Foundation Trust, London, London, UK
  4. 4 UCL Tissue Access for Patient Benefit, London, UK
  5. 5 Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA
  6. 6 Department of Liver Transplantation, HPB and Hepatology, Royal Free London NHS Foundation Trust, London, UK
  7. 7 Department of Clinical Biochemistry, King’s College Hospital NHS Foundation Trust, London, UK
  8. 8 Department of Clinical Biochemistry, Royal Free London NHS Foundation Trust, London, UK
  1. Correspondence to Dr Gautam Mehta; gautam.mehta{at}ucl.ac.uk

Abstract

Objective To assess changes in metabolic risk factors and cancer-related growth factors associated with short-term abstinence from alcohol.

Design Prospective, observational study.

Setting Single tertiary centre.

Participants Healthy subjects were recruited based on intention to: (1) abstain from alcohol for 1 month (abstinence group), or (2) continue to drink alcohol (control group). Inclusion criteria were baseline alcohol consumption >64 g/week (men) or >48 g/week (women). Exclusion criteria were known liver disease or alcohol dependence.

Primary and secondary outcome measures The primary outcome was change in insulin resistance (homeostatic model assessment (HOMA) score). Secondary outcomes were changes in weight, blood pressure (BP), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and liver function tests. Primary and secondary outcomes were adjusted for changes in diet, exercise and cigarette smoking.

Results The abstinence group comprised 94 participants (mean age 45.5 years, SD ±1.2) and the control group 47 participants (mean age 48.7 years, SD ±1.8). Baseline alcohol consumption in the abstinence group was 258.2 g/week, SD ±9.4, and in the control group 233.8 g, SD ±19.0. Significant reductions from baseline in the abstinence group (all p<0.001) were found in: HOMA score (−25.9%, IQR −48.6% to +0.3%), systolic BP (−6.6%, IQR −11.8% to 0.0%), diastolic BP (−6.3%, IQR −14.1% to +1.3%), weight (−1.5%, IQR −2.9% to −0.4%), VEGF (−41.8%, IQR −64.9% to −17.9%) and EGF (−73.9%, IQR −86.1% to −36.4%). None of these changes were associated with changes in diet, exercise or cigarette smoking. No significant changes from baseline in primary or secondary outcomes were noted in the control group.

Conclusion These findings demonstrate that abstinence from alcohol in moderate–heavy drinkers improves insulin resistance, weight, BP and cancer-related growth factors. These data support an independent association of alcohol consumption with cancer risk, and suggest an increased risk of metabolic diseases such as type 2 diabetes and fatty liver disease.

  • alcohol
  • insulin resistance
  • cancer
  • fatty liver

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Footnotes

  • Contributors GM contributed to the study design, participated in data collection, wrote the analytical plan and drafted and revised the paper. He is the guarantor. SM participated in the study design, participated in data collection and drafted and revised the paper. AC and TK-B analysed the data, and drafted and revised the paper. CS participated in study design and revision of the paper. MR, SA-K, AJ, CC, JM, AG and TH participated in data collection and revision of the paper. CJ, RS, DN and RJ contributed to the study design and revision of the paper. KM supervised the study, contributed to the study design, participated in data collection and drafted and revised the paper.

  • Funding This work was funded by the Royal Free Charity, Camden and Islington Public Health and the Royal Free London NHS Foundation Trust.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval NRES Committee North West (14/NW/1510).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement All raw data are available on request from the corresponding author.

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